Neratinib protects pancreatic beta cells in diabetes

The loss of functional insulin-producing β-cells is a hallmark of diabetes. Mammalian sterile 20-like kinase 1 (MST1) is a key regulator of pancreatic β-cell death and dysfunction; its deficiency restores functional β-cells and normoglycemia. The identification of MST1 inhibitors represents a promis...

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Detalles Bibliográficos
Autores principales: Ardestani, Amin, Li, Sijia, Annamalai, Karthika, Lupse, Blaz, Geravandi, Shirin, Dobrowolski, Aleksandra, Yu, Shan, Zhu, Siying, Baguley, Tyler D., Surakattula, Murali, Oetjen, Janina, Hauberg-Lotte, Lena, Herranz, Raquel, Awal, Sushil, Altenhofen, Delsi, Nguyen-Tran, Van, Joseph, Sean, Schultz, Peter G., Chatterjee, Arnab K., Rogers, Nikki, Tremblay, Matthew S., Shen, Weijun, Maedler, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825211/
https://www.ncbi.nlm.nih.gov/pubmed/31676778
http://dx.doi.org/10.1038/s41467-019-12880-5

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