Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

Chemotherapy-resistant cancer recurrence is a major cause of mortality. In acute myeloid leukemia (AML), chemorefractory relapses result from the complex interplay between altered genetic, epigenetic and transcriptional states in leukemic cells. Here, we develop an experimental model system using in...

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Detalles Bibliográficos
Autores principales: Caiado, Francisco, Maia-Silva, Diogo, Jardim, Carolina, Schmolka, Nina, Carvalho, Tânia, Reforço, Cláudia, Faria, Rita, Kolundzija, Branka, Simões, André E., Baubec, Tuncay, Vakoc, Christopher R., da Silva, Maria Gomes, Manz, Markus G., Schumacher, Ton N., Norell, Håkan, Silva-Santos, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825213/
https://www.ncbi.nlm.nih.gov/pubmed/31676777
http://dx.doi.org/10.1038/s41467-019-12983-z

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