An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Peptides and biologics provide unique opportunities to modulate intracellular targets not druggable by conventional small molecules. Most peptides and biologics are fused with cationic uptake moieties or formulated into nanoparticles to facilitate delivery, but these systems typically lack potency d...

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Detalles Bibliográficos
Autores principales: Evans, Brian C., Fletcher, R. Brock, Kilchrist, Kameron V., Dailing, Eric A., Mukalel, Alvin J., Colazo, Juan M., Oliver, Matthew, Cheung-Flynn, Joyce, Brophy, Colleen M., Tierney, John W., Isenberg, Jeffrey S., Hankenson, Kurt D., Ghimire, Kedar, Lander, Cynthia, Gersbach, Charles A., Duvall, Craig L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825215/
https://www.ncbi.nlm.nih.gov/pubmed/31676764
http://dx.doi.org/10.1038/s41467-019-12906-y

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