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In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner
Voltage-gated potassium (Kv) channel dysfunction causes a variety of inherited disorders, but developing small molecules that activate Kv channels has proven challenging. We recently discovered that the inhibitory neurotransmitter γ-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and K...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825221/ https://www.ncbi.nlm.nih.gov/pubmed/31701029 http://dx.doi.org/10.1038/s42003-019-0648-3 |