Virus–Receptor Interactions: Structural Insights For Oncolytic Virus Development

Recent advancements in oncolytic virotherapy commend a special attention to developing new strategies for targeting cancer cells with oncolytic viruses (OVs). Modifications of the viral envelope or coat proteins serve as a logical mean of repurposing viruses for cancer treatment. In this review, we...

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Autores principales: Jayawardena, Nadishka, Burga, Laura N, Poirier, John T, Bostina, Mihnea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825474/
https://www.ncbi.nlm.nih.gov/pubmed/31754615
http://dx.doi.org/10.2147/OV.S218494
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author Jayawardena, Nadishka
Burga, Laura N
Poirier, John T
Bostina, Mihnea
author_facet Jayawardena, Nadishka
Burga, Laura N
Poirier, John T
Bostina, Mihnea
author_sort Jayawardena, Nadishka
collection PubMed
description Recent advancements in oncolytic virotherapy commend a special attention to developing new strategies for targeting cancer cells with oncolytic viruses (OVs). Modifications of the viral envelope or coat proteins serve as a logical mean of repurposing viruses for cancer treatment. In this review, we discuss how detailed structural knowledge of the interactions between OVs and their natural receptors provide valuable insights into tumor specificity of some viruses and re-targeting of alternate receptors for broad tumor tropism or improved tumor selectivity.
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spelling pubmed-68254742019-11-21 Virus–Receptor Interactions: Structural Insights For Oncolytic Virus Development Jayawardena, Nadishka Burga, Laura N Poirier, John T Bostina, Mihnea Oncolytic Virother Review Recent advancements in oncolytic virotherapy commend a special attention to developing new strategies for targeting cancer cells with oncolytic viruses (OVs). Modifications of the viral envelope or coat proteins serve as a logical mean of repurposing viruses for cancer treatment. In this review, we discuss how detailed structural knowledge of the interactions between OVs and their natural receptors provide valuable insights into tumor specificity of some viruses and re-targeting of alternate receptors for broad tumor tropism or improved tumor selectivity. Dove 2019-10-29 /pmc/articles/PMC6825474/ /pubmed/31754615 http://dx.doi.org/10.2147/OV.S218494 Text en © 2019 Jayawardena et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Jayawardena, Nadishka
Burga, Laura N
Poirier, John T
Bostina, Mihnea
Virus–Receptor Interactions: Structural Insights For Oncolytic Virus Development
title Virus–Receptor Interactions: Structural Insights For Oncolytic Virus Development
title_full Virus–Receptor Interactions: Structural Insights For Oncolytic Virus Development
title_fullStr Virus–Receptor Interactions: Structural Insights For Oncolytic Virus Development
title_full_unstemmed Virus–Receptor Interactions: Structural Insights For Oncolytic Virus Development
title_short Virus–Receptor Interactions: Structural Insights For Oncolytic Virus Development
title_sort virus–receptor interactions: structural insights for oncolytic virus development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825474/
https://www.ncbi.nlm.nih.gov/pubmed/31754615
http://dx.doi.org/10.2147/OV.S218494
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