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G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans

There is extensive evidence to believe that the endocannabinoid system plays an important role in energy homeostasis through a variety of mechanisms. This study aimed to analyze the association between polymorphism rs12720071 of the cannabinoid type 1 receptor (CNR1) gene with dyslipidemia and overw...

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Autores principales: Rodríguez-Rodríguez, Ismael, Fernández-Quiroga, Karla, Araujo-Moreno, Pedro, Balderas-Rentería, Isaías, Gonzalez-Santiago, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825498/
https://www.ncbi.nlm.nih.gov/pubmed/31723535
http://dx.doi.org/10.7759/cureus.5776
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author Rodríguez-Rodríguez, Ismael
Fernández-Quiroga, Karla
Araujo-Moreno, Pedro
Balderas-Rentería, Isaías
Gonzalez-Santiago, Omar
author_facet Rodríguez-Rodríguez, Ismael
Fernández-Quiroga, Karla
Araujo-Moreno, Pedro
Balderas-Rentería, Isaías
Gonzalez-Santiago, Omar
author_sort Rodríguez-Rodríguez, Ismael
collection PubMed
description There is extensive evidence to believe that the endocannabinoid system plays an important role in energy homeostasis through a variety of mechanisms. This study aimed to analyze the association between polymorphism rs12720071 of the cannabinoid type 1 receptor (CNR1) gene with dyslipidemia and overweight in young, healthy Mexicans. The association was analyzed with a logistic regression model and expressed as odds ratio (OR). A total of 148 individuals agreed to participate. Overall, the serum concentrations of lipids were found to be in the normal range. However, females presented higher levels of cholesterol and low-density lipoprotein (LDL) than males [probability value (p) = <0.05]. In addition, females presented higher risk of being overweight (BMI: >25) [OR = 3.57; 95% confidence interval (CI): 1.05-12.20; p = 0.04], than males. Our results suggest that this polymorphism could influence BMI in young females.
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spelling pubmed-68254982019-11-13 G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans Rodríguez-Rodríguez, Ismael Fernández-Quiroga, Karla Araujo-Moreno, Pedro Balderas-Rentería, Isaías Gonzalez-Santiago, Omar Cureus Endocrinology/Diabetes/Metabolism There is extensive evidence to believe that the endocannabinoid system plays an important role in energy homeostasis through a variety of mechanisms. This study aimed to analyze the association between polymorphism rs12720071 of the cannabinoid type 1 receptor (CNR1) gene with dyslipidemia and overweight in young, healthy Mexicans. The association was analyzed with a logistic regression model and expressed as odds ratio (OR). A total of 148 individuals agreed to participate. Overall, the serum concentrations of lipids were found to be in the normal range. However, females presented higher levels of cholesterol and low-density lipoprotein (LDL) than males [probability value (p) = <0.05]. In addition, females presented higher risk of being overweight (BMI: >25) [OR = 3.57; 95% confidence interval (CI): 1.05-12.20; p = 0.04], than males. Our results suggest that this polymorphism could influence BMI in young females. Cureus 2019-09-26 /pmc/articles/PMC6825498/ /pubmed/31723535 http://dx.doi.org/10.7759/cureus.5776 Text en Copyright © 2019, Rodríguez-Rodríguez et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Rodríguez-Rodríguez, Ismael
Fernández-Quiroga, Karla
Araujo-Moreno, Pedro
Balderas-Rentería, Isaías
Gonzalez-Santiago, Omar
G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans
title G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans
title_full G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans
title_fullStr G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans
title_full_unstemmed G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans
title_short G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans
title_sort g1359a polymorphism of the cannabinoid receptor 1 is not associated with overweight and dyslipidemia in young northeastern mexicans
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825498/
https://www.ncbi.nlm.nih.gov/pubmed/31723535
http://dx.doi.org/10.7759/cureus.5776
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