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G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans
There is extensive evidence to believe that the endocannabinoid system plays an important role in energy homeostasis through a variety of mechanisms. This study aimed to analyze the association between polymorphism rs12720071 of the cannabinoid type 1 receptor (CNR1) gene with dyslipidemia and overw...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825498/ https://www.ncbi.nlm.nih.gov/pubmed/31723535 http://dx.doi.org/10.7759/cureus.5776 |
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author | Rodríguez-Rodríguez, Ismael Fernández-Quiroga, Karla Araujo-Moreno, Pedro Balderas-Rentería, Isaías Gonzalez-Santiago, Omar |
author_facet | Rodríguez-Rodríguez, Ismael Fernández-Quiroga, Karla Araujo-Moreno, Pedro Balderas-Rentería, Isaías Gonzalez-Santiago, Omar |
author_sort | Rodríguez-Rodríguez, Ismael |
collection | PubMed |
description | There is extensive evidence to believe that the endocannabinoid system plays an important role in energy homeostasis through a variety of mechanisms. This study aimed to analyze the association between polymorphism rs12720071 of the cannabinoid type 1 receptor (CNR1) gene with dyslipidemia and overweight in young, healthy Mexicans. The association was analyzed with a logistic regression model and expressed as odds ratio (OR). A total of 148 individuals agreed to participate. Overall, the serum concentrations of lipids were found to be in the normal range. However, females presented higher levels of cholesterol and low-density lipoprotein (LDL) than males [probability value (p) = <0.05]. In addition, females presented higher risk of being overweight (BMI: >25) [OR = 3.57; 95% confidence interval (CI): 1.05-12.20; p = 0.04], than males. Our results suggest that this polymorphism could influence BMI in young females. |
format | Online Article Text |
id | pubmed-6825498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-68254982019-11-13 G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans Rodríguez-Rodríguez, Ismael Fernández-Quiroga, Karla Araujo-Moreno, Pedro Balderas-Rentería, Isaías Gonzalez-Santiago, Omar Cureus Endocrinology/Diabetes/Metabolism There is extensive evidence to believe that the endocannabinoid system plays an important role in energy homeostasis through a variety of mechanisms. This study aimed to analyze the association between polymorphism rs12720071 of the cannabinoid type 1 receptor (CNR1) gene with dyslipidemia and overweight in young, healthy Mexicans. The association was analyzed with a logistic regression model and expressed as odds ratio (OR). A total of 148 individuals agreed to participate. Overall, the serum concentrations of lipids were found to be in the normal range. However, females presented higher levels of cholesterol and low-density lipoprotein (LDL) than males [probability value (p) = <0.05]. In addition, females presented higher risk of being overweight (BMI: >25) [OR = 3.57; 95% confidence interval (CI): 1.05-12.20; p = 0.04], than males. Our results suggest that this polymorphism could influence BMI in young females. Cureus 2019-09-26 /pmc/articles/PMC6825498/ /pubmed/31723535 http://dx.doi.org/10.7759/cureus.5776 Text en Copyright © 2019, Rodríguez-Rodríguez et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Rodríguez-Rodríguez, Ismael Fernández-Quiroga, Karla Araujo-Moreno, Pedro Balderas-Rentería, Isaías Gonzalez-Santiago, Omar G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans |
title | G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans |
title_full | G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans |
title_fullStr | G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans |
title_full_unstemmed | G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans |
title_short | G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans |
title_sort | g1359a polymorphism of the cannabinoid receptor 1 is not associated with overweight and dyslipidemia in young northeastern mexicans |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825498/ https://www.ncbi.nlm.nih.gov/pubmed/31723535 http://dx.doi.org/10.7759/cureus.5776 |
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