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Relationship between Ocular Surface Alterations and Concentrations of Aerial Particulate Matter

PURPOSE: To evaluate ocular surface alterations in two populations at different exposure levels to particulate matter (PM) in their living and work environments. METHODS: A cross-sectional study was conducted, including 78 volunteers from Argentina who lived and worked under different pollution leve...

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Autores principales: Gutiérrez, María A, Giuliani, Daniela, Porta, Atilio A, Andrinolo, Darío
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PUBLISHED BY KNOWLEDGE E 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825693/
https://www.ncbi.nlm.nih.gov/pubmed/31875096
http://dx.doi.org/10.18502/jovr.v14i4.5441
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author Gutiérrez, María A
Giuliani, Daniela
Porta, Atilio A
Andrinolo, Darío
author_facet Gutiérrez, María A
Giuliani, Daniela
Porta, Atilio A
Andrinolo, Darío
author_sort Gutiérrez, María A
collection PubMed
description PURPOSE: To evaluate ocular surface alterations in two populations at different exposure levels to particulate matter (PM) in their living and work environments. METHODS: A cross-sectional study was conducted, including 78 volunteers from Argentina who lived and worked under different pollution levels in an urban (U; n = 44) or industrial zone (I; n = 34). Mean exposure level to PM was evaluated. Responses to the Ocular Symptom Disease Index and McMonnies questionnaire were obtained from all subjects. Subsequently, an assessment through the Schirmer I test (ST), slit lamp microscopy, vital staining, and tear breakup time was conducted. Statistical analyses with Chi-square and Bartlett's tests, as well as Student's t-tests and principal component analysis (PCA), were performed. RESULTS: Particles of size [Formula: see text] 2.5 μm (PM [Formula: see text]) level was significantly higher in the I group than the U group (P = 0.04). Ocular surface parameters including bulbar redness, eyelid redness, and the degree of vital staining with fluorescein (SF) and lissamine green (SLG) exhibited difference between the groups. With regards to the tear film, statistically significant differences in the ST value and meibomian gland dysfunction between the groups were detected (P = 0.003 and P = 0.02, respectively). Conjunctival SF and SLG, and ST values were identified as factors which could distinguish groups exposed to different PM levels. CONCLUSION: Subjects exposed to higher levels of PM in the outdoor air presented greater ocular surface alterations. Thus, ST, SF, and SLG values could be used as convenient indicators of adverse health effects due to exposure to air pollution.
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spelling pubmed-68256932019-12-24 Relationship between Ocular Surface Alterations and Concentrations of Aerial Particulate Matter Gutiérrez, María A Giuliani, Daniela Porta, Atilio A Andrinolo, Darío J Ophthalmic Vis Res Original Article PURPOSE: To evaluate ocular surface alterations in two populations at different exposure levels to particulate matter (PM) in their living and work environments. METHODS: A cross-sectional study was conducted, including 78 volunteers from Argentina who lived and worked under different pollution levels in an urban (U; n = 44) or industrial zone (I; n = 34). Mean exposure level to PM was evaluated. Responses to the Ocular Symptom Disease Index and McMonnies questionnaire were obtained from all subjects. Subsequently, an assessment through the Schirmer I test (ST), slit lamp microscopy, vital staining, and tear breakup time was conducted. Statistical analyses with Chi-square and Bartlett's tests, as well as Student's t-tests and principal component analysis (PCA), were performed. RESULTS: Particles of size [Formula: see text] 2.5 μm (PM [Formula: see text]) level was significantly higher in the I group than the U group (P = 0.04). Ocular surface parameters including bulbar redness, eyelid redness, and the degree of vital staining with fluorescein (SF) and lissamine green (SLG) exhibited difference between the groups. With regards to the tear film, statistically significant differences in the ST value and meibomian gland dysfunction between the groups were detected (P = 0.003 and P = 0.02, respectively). Conjunctival SF and SLG, and ST values were identified as factors which could distinguish groups exposed to different PM levels. CONCLUSION: Subjects exposed to higher levels of PM in the outdoor air presented greater ocular surface alterations. Thus, ST, SF, and SLG values could be used as convenient indicators of adverse health effects due to exposure to air pollution. PUBLISHED BY KNOWLEDGE E 2019-10-24 /pmc/articles/PMC6825693/ /pubmed/31875096 http://dx.doi.org/10.18502/jovr.v14i4.5441 Text en Copyright © 2019 Gutiérrez et al. https://creativecommons.org/licenses/by/4.0/ This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Gutiérrez, María A
Giuliani, Daniela
Porta, Atilio A
Andrinolo, Darío
Relationship between Ocular Surface Alterations and Concentrations of Aerial Particulate Matter
title Relationship between Ocular Surface Alterations and Concentrations of Aerial Particulate Matter
title_full Relationship between Ocular Surface Alterations and Concentrations of Aerial Particulate Matter
title_fullStr Relationship between Ocular Surface Alterations and Concentrations of Aerial Particulate Matter
title_full_unstemmed Relationship between Ocular Surface Alterations and Concentrations of Aerial Particulate Matter
title_short Relationship between Ocular Surface Alterations and Concentrations of Aerial Particulate Matter
title_sort relationship between ocular surface alterations and concentrations of aerial particulate matter
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825693/
https://www.ncbi.nlm.nih.gov/pubmed/31875096
http://dx.doi.org/10.18502/jovr.v14i4.5441
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