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Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases

Tau is a microtubule-associated protein, which is highly expressed in the central nervous system as well as ocular neurons and stabilizes microtubule structure. It is a phospho-protein being moderately phosphorylated under physiological conditions but its abnormal hyperphosphorylation or some post-p...

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Autores principales: Mishan, Mohammad Amir, Kanavi, Mozhgan Rezaei, Shahpasand, Koorosh, Ahmadieh, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PUBLISHED BY KNOWLEDGE E 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825701/
https://www.ncbi.nlm.nih.gov/pubmed/31875105
http://dx.doi.org/10.18502/jovr.v14i4.5459
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author Mishan, Mohammad Amir
Kanavi, Mozhgan Rezaei
Shahpasand, Koorosh
Ahmadieh, Hamid
author_facet Mishan, Mohammad Amir
Kanavi, Mozhgan Rezaei
Shahpasand, Koorosh
Ahmadieh, Hamid
author_sort Mishan, Mohammad Amir
collection PubMed
description Tau is a microtubule-associated protein, which is highly expressed in the central nervous system as well as ocular neurons and stabilizes microtubule structure. It is a phospho-protein being moderately phosphorylated under physiological conditions but its abnormal hyperphosphorylation or some post-phosphorylation modifications would result in a pathogenic condition, microtubule dissociation, and aggregation. The aggregates can induce neuroinflammation and trigger some pathogenic cascades, leading to neurodegeneration. Taking these together, targeting pathogenic tau employing tau immunotherapy may be a promising therapeutic strategy in fighting with cerebral and ocular neurodegenerative disorders.
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spelling pubmed-68257012019-12-24 Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases Mishan, Mohammad Amir Kanavi, Mozhgan Rezaei Shahpasand, Koorosh Ahmadieh, Hamid J Ophthalmic Vis Res Review Article Tau is a microtubule-associated protein, which is highly expressed in the central nervous system as well as ocular neurons and stabilizes microtubule structure. It is a phospho-protein being moderately phosphorylated under physiological conditions but its abnormal hyperphosphorylation or some post-phosphorylation modifications would result in a pathogenic condition, microtubule dissociation, and aggregation. The aggregates can induce neuroinflammation and trigger some pathogenic cascades, leading to neurodegeneration. Taking these together, targeting pathogenic tau employing tau immunotherapy may be a promising therapeutic strategy in fighting with cerebral and ocular neurodegenerative disorders. PUBLISHED BY KNOWLEDGE E 2019-10-24 /pmc/articles/PMC6825701/ /pubmed/31875105 http://dx.doi.org/10.18502/jovr.v14i4.5459 Text en Copyright © 2019 Mishan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Mishan, Mohammad Amir
Kanavi, Mozhgan Rezaei
Shahpasand, Koorosh
Ahmadieh, Hamid
Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases
title Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases
title_full Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases
title_fullStr Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases
title_full_unstemmed Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases
title_short Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases
title_sort pathogenic tau protein species: promising therapeutic targets for ocular neurodegenerative diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825701/
https://www.ncbi.nlm.nih.gov/pubmed/31875105
http://dx.doi.org/10.18502/jovr.v14i4.5459
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