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Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases
Tau is a microtubule-associated protein, which is highly expressed in the central nervous system as well as ocular neurons and stabilizes microtubule structure. It is a phospho-protein being moderately phosphorylated under physiological conditions but its abnormal hyperphosphorylation or some post-p...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PUBLISHED BY KNOWLEDGE E
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825701/ https://www.ncbi.nlm.nih.gov/pubmed/31875105 http://dx.doi.org/10.18502/jovr.v14i4.5459 |
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author | Mishan, Mohammad Amir Kanavi, Mozhgan Rezaei Shahpasand, Koorosh Ahmadieh, Hamid |
author_facet | Mishan, Mohammad Amir Kanavi, Mozhgan Rezaei Shahpasand, Koorosh Ahmadieh, Hamid |
author_sort | Mishan, Mohammad Amir |
collection | PubMed |
description | Tau is a microtubule-associated protein, which is highly expressed in the central nervous system as well as ocular neurons and stabilizes microtubule structure. It is a phospho-protein being moderately phosphorylated under physiological conditions but its abnormal hyperphosphorylation or some post-phosphorylation modifications would result in a pathogenic condition, microtubule dissociation, and aggregation. The aggregates can induce neuroinflammation and trigger some pathogenic cascades, leading to neurodegeneration. Taking these together, targeting pathogenic tau employing tau immunotherapy may be a promising therapeutic strategy in fighting with cerebral and ocular neurodegenerative disorders. |
format | Online Article Text |
id | pubmed-6825701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | PUBLISHED BY KNOWLEDGE E |
record_format | MEDLINE/PubMed |
spelling | pubmed-68257012019-12-24 Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases Mishan, Mohammad Amir Kanavi, Mozhgan Rezaei Shahpasand, Koorosh Ahmadieh, Hamid J Ophthalmic Vis Res Review Article Tau is a microtubule-associated protein, which is highly expressed in the central nervous system as well as ocular neurons and stabilizes microtubule structure. It is a phospho-protein being moderately phosphorylated under physiological conditions but its abnormal hyperphosphorylation or some post-phosphorylation modifications would result in a pathogenic condition, microtubule dissociation, and aggregation. The aggregates can induce neuroinflammation and trigger some pathogenic cascades, leading to neurodegeneration. Taking these together, targeting pathogenic tau employing tau immunotherapy may be a promising therapeutic strategy in fighting with cerebral and ocular neurodegenerative disorders. PUBLISHED BY KNOWLEDGE E 2019-10-24 /pmc/articles/PMC6825701/ /pubmed/31875105 http://dx.doi.org/10.18502/jovr.v14i4.5459 Text en Copyright © 2019 Mishan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Mishan, Mohammad Amir Kanavi, Mozhgan Rezaei Shahpasand, Koorosh Ahmadieh, Hamid Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases |
title | Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases |
title_full | Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases |
title_fullStr | Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases |
title_full_unstemmed | Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases |
title_short | Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases |
title_sort | pathogenic tau protein species: promising therapeutic targets for ocular neurodegenerative diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825701/ https://www.ncbi.nlm.nih.gov/pubmed/31875105 http://dx.doi.org/10.18502/jovr.v14i4.5459 |
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