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Total Body Irradiation and Risk of Diabetes Mellitus; A Meta-Analysis
OBJECTIVE: Hematopoietic stem cell transplant (HSCT) has recently emerged as a cure for previously “incurable” diseases and is being explored and attempted in many other fields including congenital and acquired non-malignant diseases. However, the long-term side effect associated with HSCT especiall...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825782/ https://www.ncbi.nlm.nih.gov/pubmed/30912408 http://dx.doi.org/10.31557/APJCP.2019.20.3.885 |
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author | Poonsombudlert, Kittika Limpruttidham, Nath |
author_facet | Poonsombudlert, Kittika Limpruttidham, Nath |
author_sort | Poonsombudlert, Kittika |
collection | PubMed |
description | OBJECTIVE: Hematopoietic stem cell transplant (HSCT) has recently emerged as a cure for previously “incurable” diseases and is being explored and attempted in many other fields including congenital and acquired non-malignant diseases. However, the long-term side effect associated with HSCT especially Total Body Irradiation (TBI) is still understudied. Therefore, we attempted to establish association between TBI and risk of developing Diabetes Mellitus (DM) or impaired glucose metabolism (IGM). METHODS: We searched for titles of articles in MEDLINE (PubMed), EMBASE, and Cochrane library in August 2018 that evaluated the association between TBI in the setting of HSCT and DM or IGM. We conducted a random effect meta-analysis of 11 studies involving a total of 13,191 participants and reported the pooled MD (mean difference) for the development of DM/IGM after TBI as part of the conditioning regimen for HSCT. RESULTS: We found a significant increase in the risk of developing DM/IGM after TBI is used as part of the conditioning regimen compared to other types of conditioning regimen with the pooled MD being 5.42, 95% Confidence Interval (CI) 2.51-11.71, I2=92.4%. CONCLUSION: TBI as a conditioning regimen in the setting of HSCT significantly increases the risk of developing DM/IGM. Therefore, we recommend close monitoring and screening for diabetes mellitus in patients who underwent TBI before HSCT. |
format | Online Article Text |
id | pubmed-6825782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-68257822019-11-21 Total Body Irradiation and Risk of Diabetes Mellitus; A Meta-Analysis Poonsombudlert, Kittika Limpruttidham, Nath Asian Pac J Cancer Prev Research Article OBJECTIVE: Hematopoietic stem cell transplant (HSCT) has recently emerged as a cure for previously “incurable” diseases and is being explored and attempted in many other fields including congenital and acquired non-malignant diseases. However, the long-term side effect associated with HSCT especially Total Body Irradiation (TBI) is still understudied. Therefore, we attempted to establish association between TBI and risk of developing Diabetes Mellitus (DM) or impaired glucose metabolism (IGM). METHODS: We searched for titles of articles in MEDLINE (PubMed), EMBASE, and Cochrane library in August 2018 that evaluated the association between TBI in the setting of HSCT and DM or IGM. We conducted a random effect meta-analysis of 11 studies involving a total of 13,191 participants and reported the pooled MD (mean difference) for the development of DM/IGM after TBI as part of the conditioning regimen for HSCT. RESULTS: We found a significant increase in the risk of developing DM/IGM after TBI is used as part of the conditioning regimen compared to other types of conditioning regimen with the pooled MD being 5.42, 95% Confidence Interval (CI) 2.51-11.71, I2=92.4%. CONCLUSION: TBI as a conditioning regimen in the setting of HSCT significantly increases the risk of developing DM/IGM. Therefore, we recommend close monitoring and screening for diabetes mellitus in patients who underwent TBI before HSCT. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC6825782/ /pubmed/30912408 http://dx.doi.org/10.31557/APJCP.2019.20.3.885 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License |
spellingShingle | Research Article Poonsombudlert, Kittika Limpruttidham, Nath Total Body Irradiation and Risk of Diabetes Mellitus; A Meta-Analysis |
title | Total Body Irradiation and Risk of Diabetes Mellitus; A Meta-Analysis |
title_full | Total Body Irradiation and Risk of Diabetes Mellitus; A Meta-Analysis |
title_fullStr | Total Body Irradiation and Risk of Diabetes Mellitus; A Meta-Analysis |
title_full_unstemmed | Total Body Irradiation and Risk of Diabetes Mellitus; A Meta-Analysis |
title_short | Total Body Irradiation and Risk of Diabetes Mellitus; A Meta-Analysis |
title_sort | total body irradiation and risk of diabetes mellitus; a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825782/ https://www.ncbi.nlm.nih.gov/pubmed/30912408 http://dx.doi.org/10.31557/APJCP.2019.20.3.885 |
work_keys_str_mv | AT poonsombudlertkittika totalbodyirradiationandriskofdiabetesmellitusametaanalysis AT limpruttidhamnath totalbodyirradiationandriskofdiabetesmellitusametaanalysis |