Novel mechanism of impaired metabolism‐secretion coupling in β‐cells: Loss of cytosolic adenosine triphosphate by leakage

Zhang et al. recently proposed a new mechanism of metabolism‐secretion coupling impairment in diabetic β‐cells involving the loss of cytosolic adenosine triphosphate by leakage through plasma membrane. Hyperglycemia increases mistargeting expression of the adenosine triphosphate‐conducting mitochondrial outer membrane voltage‐dependent anion channel‐1 on the plasma membrane leading to adenosine triphosphate depletion. The interaction between reactive oxygen species overproduction and voltage‐dependent anion channel‐1 induction is an interesting issue to be resolved.[Image: see text]