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M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue
Adipose tissue (AT) is composed not only of adipocytes, but also of macrophages, endothelial cells and preadipocytes. Macrophages are an important component of AT, and are involved in tissue homeostasis, tissue repair and fibrosis. AT‐resident macrophages are categorized into two subtypes, the M1‐li...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825922/ https://www.ncbi.nlm.nih.gov/pubmed/31293080 http://dx.doi.org/10.1111/jdi.13114 |
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author | Nawaz, Allah Tobe, Kazuyuki |
author_facet | Nawaz, Allah Tobe, Kazuyuki |
author_sort | Nawaz, Allah |
collection | PubMed |
description | Adipose tissue (AT) is composed not only of adipocytes, but also of macrophages, endothelial cells and preadipocytes. Macrophages are an important component of AT, and are involved in tissue homeostasis, tissue repair and fibrosis. AT‐resident macrophages are categorized into two subtypes, the M1‐like and M2‐like macrophages. M2‐like macrophages are reported to play anti‐inflammatory roles, and to be involved in clearing and removal of dying/dead adipocytes, and recruiting adipocyte progenitors (APs). M2‐like macrophages are also reported to be involved in the promotion of fibrosis in a transforming growth factor‐β‐dependent manner. However, the precise roles of M2‐like macrophages in the AT have not yet been clearly delineated. Recently, we generated genetically engineered transgenic mice in which CD206(+) M2‐like macrophages can be conditionally depleted. Unexpectedly, we found that the depletion of CD206(+) M2‐like macrophages resulted in the enhanced generation of smaller adipocytes, improved insulin sensitivity and proliferation of APs. We further clarified that the CD206(+) M2‐like macrophages directly interact with the APs to regulate their growth/differentiation and adipogenesis, thereby controlling adiposity and systemic insulin sensitivity. In the present review, we discuss how CD206(+) M2‐like macrophages provide a niche for APs and maintain glucose homeostasis. |
format | Online Article Text |
id | pubmed-6825922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68259222019-11-07 M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue Nawaz, Allah Tobe, Kazuyuki J Diabetes Investig Review Article Adipose tissue (AT) is composed not only of adipocytes, but also of macrophages, endothelial cells and preadipocytes. Macrophages are an important component of AT, and are involved in tissue homeostasis, tissue repair and fibrosis. AT‐resident macrophages are categorized into two subtypes, the M1‐like and M2‐like macrophages. M2‐like macrophages are reported to play anti‐inflammatory roles, and to be involved in clearing and removal of dying/dead adipocytes, and recruiting adipocyte progenitors (APs). M2‐like macrophages are also reported to be involved in the promotion of fibrosis in a transforming growth factor‐β‐dependent manner. However, the precise roles of M2‐like macrophages in the AT have not yet been clearly delineated. Recently, we generated genetically engineered transgenic mice in which CD206(+) M2‐like macrophages can be conditionally depleted. Unexpectedly, we found that the depletion of CD206(+) M2‐like macrophages resulted in the enhanced generation of smaller adipocytes, improved insulin sensitivity and proliferation of APs. We further clarified that the CD206(+) M2‐like macrophages directly interact with the APs to regulate their growth/differentiation and adipogenesis, thereby controlling adiposity and systemic insulin sensitivity. In the present review, we discuss how CD206(+) M2‐like macrophages provide a niche for APs and maintain glucose homeostasis. John Wiley and Sons Inc. 2019-08-05 2019-11 /pmc/articles/PMC6825922/ /pubmed/31293080 http://dx.doi.org/10.1111/jdi.13114 Text en © 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Article Nawaz, Allah Tobe, Kazuyuki M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue |
title | M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue |
title_full | M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue |
title_fullStr | M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue |
title_full_unstemmed | M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue |
title_short | M2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue |
title_sort | m2‐like macrophages serve as a niche for adipocyte progenitors in adipose tissue |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825922/ https://www.ncbi.nlm.nih.gov/pubmed/31293080 http://dx.doi.org/10.1111/jdi.13114 |
work_keys_str_mv | AT nawazallah m2likemacrophagesserveasanicheforadipocyteprogenitorsinadiposetissue AT tobekazuyuki m2likemacrophagesserveasanicheforadipocyteprogenitorsinadiposetissue |