Longitudinal impact of dapagliflozin treatment on ventricular repolarization heterogeneity in patients with type 2 diabetes

QTc dispersion (QTcd) tended to be decreased at 24 weeks and was significantly decreased at 2 years after dapagliflozin treatment. In the subgroup with QTcd?53.7 ms (median), QTcd was significantly decreased at 24 weeks and remained improved for 2 years. Dapagliflozin also significantly reduced Tpea...

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Detalles Bibliográficos
Autores principales: Sato, Tatsuya, Miki, Takayuki, Furukawa, Shinya, Matsuura, Bunzo, Hiasa, Yoichi, Ohnishi, Hirofumi, Tanno, Masaya, Miura, Tetsuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825944/
https://www.ncbi.nlm.nih.gov/pubmed/31090258
http://dx.doi.org/10.1111/jdi.13063
Descripción
Sumario:QTc dispersion (QTcd) tended to be decreased at 24 weeks and was significantly decreased at 2 years after dapagliflozin treatment. In the subgroup with QTcd?53.7 ms (median), QTcd was significantly decreased at 24 weeks and remained improved for 2 years. Dapagliflozin also significantly reduced Tpeak‐Tend/QT in a subgroup with Tpeak‐Tend/QT?0.25 (median).[Image: see text]

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