Cargando…

The TRPA1 Ion Channel Contributes to Sensory-Guided Avoidance of Menthol in Mice

The flavoring agent menthol elicits complex orosensory and behavioral effects including perceived cooling at low concentrations and irritation and ingestive avoidance at higher intensities. Oral menthol engages the cold-activated transient receptor potential (TRP) ion channel TRP melastatin 8 (TRPM8...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lemon, Christian H., Norris, Jordan E., Heldmann, Bradley A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2019
Materias:	New Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825956/ https://www.ncbi.nlm.nih.gov/pubmed/31624176 http://dx.doi.org/10.1523/ENEURO.0304-19.2019

Ejemplares similares

Sensory Neuron-Specific Deletion of TRPA1 Results in Mechanical Cutaneous Sensory Deficits
por: Zappia, Katherine J., et al.
Publicado: (2017)

HsTRPA of the Red Imported Fire Ant, Solenopsis invicta, Functions as a Nocisensor and Uncovers the Evolutionary Plasticity of HsTRPA Channels
por: Wang, Xinyue, et al.
Publicado: (2018)

Activation of Drosophila melanogaster TRPA1 Isoforms by Citronellal and Menthol
por: Boonen, Brett, et al.
Publicado: (2021)

The exceptionally high reactivity of Cys 621 is critical for electrophilic activation of the sensory nerve ion channel TRPA1
por: Bahia, Parmvir K., et al.
Publicado: (2016)

Modulation of TRPA1 channel activity by Cdk5 in sensory neurons
por: Sulak, Michael A., et al.
Publicado: (2018)

Australian Smokers’ Sensory Experiences and Beliefs Associated with Menthol and Non-Menthol Cigarettes
por: Mancuso, Serafino, et al.
Publicado: (2021)

Sensory properties of menthol and smoking topography
por: Lawrence, Deirdre, et al.
Publicado: (2011)

The Role of TRPA1 Channels in the Central Processing of Odours Contributing to the Behavioural Responses of Mice
por: Konkoly, János, et al.
Publicado: (2021)

Structure of the TRPA1 ion channel suggests regulatory mechanisms
por: Paulsen, Candice E., et al.
Publicado: (2015)

Atypical pharmacology of schistosome TRPA1-like ion channels
por: Bais, Swarna, et al.
Publicado: (2018)

Slack Potassium Channels Modulate TRPA1-Mediated Nociception in Sensory Neurons
por: Zhou, Fangyuan, et al.
Publicado: (2022)

Warmth suppresses and desensitizes damage-sensing ion channel TRPA1
por: Wang, Sen, et al.
Publicado: (2012)

Multimerization of Homo sapiens TRPA1 ion channel cytoplasmic domains
por: Martinez, Gilbert Q., et al.
Publicado: (2019)

Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel
por: Xu, Lizhen, et al.
Publicado: (2020)

Slow Inactivation of Sodium Channels Contributes to Short-Term Adaptation in Vomeronasal Sensory Neurons
por: Sarno, Nicole, et al.
Publicado: (2022)

Impact of menthol delivery methods on smoker sensory perceptions
por: Schneller, Liane, et al.
Publicado: (2020)

Ligand determinants of fatty acid activation of the pronociceptive ion channel TRPA1
por: Redmond, William John, et al.
Publicado: (2014)

Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation
por: Lindsay, Christopher D., et al.
Publicado: (2015)

Structural Modeling of TRPA1 Ion Channel—Determination of the Binding Site for Antagonists
por: Gawalska, Alicja, et al.
Publicado: (2022)

The Contribution of TRPM8 and TRPA1 Channels to Cold Allodynia and Neuropathic Pain
por: Caspani, Ombretta, et al.
Publicado: (2009)

TRPV1, but not TRPA1, in primary sensory neurons contributes to cutaneous incision-mediated hypersensitivity
por: Barabas, Marie E, et al.
Publicado: (2013)

Inflammation—the role of TRPA1 channel
por: Yao, Kaifang, et al.
Publicado: (2023)

The role of TRPA1 channels in thermosensation
por: Zhang, Hao, et al.
Publicado: (2022)

Menthol Stereoisomers Exhibit Different Effects on α4β2 nAChR Upregulation and Dopamine Neuron Spontaneous Firing
por: Henderson, Brandon J., et al.
Publicado: (2019)

Contribution of CD137L to Sensory Hypersensitivity in a Murine Model of Neuropathic Pain
por: Wakley, Alexa A., et al.
Publicado: (2018)

Wu-Tou Decoction Inhibits Chronic Inflammatory Pain in Mice: Participation of TRPV1 and TRPA1 Ion Channels
por: Wang, Chao, et al.
Publicado: (2015)

Selective activation of TRPA1 ion channels by nitrobenzene skin sensitizers DNFB and DNCB
por: Wu, Han, et al.
Publicado: (2021)

Functional evidence of distinct electrophile-induced activation states of the ion channel TRPA1
por: Parks, Thomas A., et al.
Publicado: (2021)

Contribution of Drosophila TRPA1 to Metabolism
por: Lee, Jung-Eun, et al.
Publicado: (2016)

TRPA1 Channel is Involved in SLIGRL-Evoked Thermal and Mechanical Hyperalgesia in Mice
por: Tsagareli, Merab G., et al.
Publicado: (2019)

The Sensory Difference Threshold of Menthol Odor in Flavored Tobacco Determined by Combining Sensory and Chemical Analysis
por: Krüsemann, Erna J.Z., et al.
Publicado: (2017)

Electrophile-Induced Conformational Switch of the Human TRPA1 Ion Channel Detected by Mass Spectrometry
por: Moparthi, Lavanya, et al.
Publicado: (2020)

Prerequisite Binding Modes Determine the Dynamics of Action of Covalent Agonists of Ion Channel TRPA1
por: Zsidó, Balázs Zoltán, et al.
Publicado: (2021)

TRPA1 and other TRP channels in migraine
por: Benemei, Silvia, et al.
Publicado: (2013)

Sensory Adaptation to Chemical Cues by Vomeronasal Sensory Neurons
por: Wong, Wen Mai, et al.
Publicado: (2018)

Effect of Skin Ion Channel TRPM8 Activation by Cold and Menthol on Thermoregulation and the Expression of Genes of Thermosensitive TRP Ion Channels in the Hypothalamus of Hypertensive Rats
por: Voronova, Irina P., et al.
Publicado: (2022)

Excessive Sensory Stimulation during Development Alters Neural Plasticity and Vulnerability to Cocaine in Mice
por: Ravinder, Shilpa, et al.
Publicado: (2016)

Propofol Causes Vasodilation In Vivo via TRPA1 Ion Channels: Role of Nitric Oxide and BK(Ca) Channels
por: Sinha, Sayantani, et al.
Publicado: (2015)

Schistosomes contain divergent ligand-gated ion channels with an atypical Cys-loop motif
por: Johnson, Hailey, et al.
Publicado: (2023)

TRPA1 activation in non-sensory supporting cells contributes to regulation of cochlear sensitivity after acoustic trauma
por: Vélez-Ortega, A. Catalina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9egs0ra8nt4j8nh6it900ipemh