IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset

Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases. Incidence of drug hypersensitivity reactions (DHRs) to PPIs has been rising, presumably because of their increased consumption. Most DHR are IgE-mediated, with half of the reactions being anaphylactic. We d...

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Detalles Bibliográficos
Autores principales: Barakat, Leyla, Vasconcelos, Maria João, Bourrain, Jean Luc, Demoly, Pascal, Chiriac, Anca-Mirela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2019
Materias:
Hypothesis & Experience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826111/
https://www.ncbi.nlm.nih.gov/pubmed/31720241
http://dx.doi.org/10.5415/apallergy.2019.9.e30
Descripción
Sumario:Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases. Incidence of drug hypersensitivity reactions (DHRs) to PPIs has been rising, presumably because of their increased consumption. Most DHR are IgE-mediated, with half of the reactions being anaphylactic. We describe the case of a Caucasian 50-year-old female patient referred to our allergy department after 2 episodes of anaphylaxis. The allergy work-up distinguished PPI as a cause of delayed onset (14 hours) and immediate onset (45 minutes) IgE-mediated DHR.

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