IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset

Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases. Incidence of drug hypersensitivity reactions (DHRs) to PPIs has been rising, presumably because of their increased consumption. Most DHR are IgE-mediated, with half of the reactions being anaphylactic. We d...

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Autores principales: Barakat, Leyla, Vasconcelos, Maria João, Bourrain, Jean Luc, Demoly, Pascal, Chiriac, Anca-Mirela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2019
Materias:
Hypothesis & Experience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826111/
https://www.ncbi.nlm.nih.gov/pubmed/31720241
http://dx.doi.org/10.5415/apallergy.2019.9.e30
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author Barakat, Leyla
Vasconcelos, Maria João
Bourrain, Jean Luc
Demoly, Pascal
Chiriac, Anca-Mirela
author_facet Barakat, Leyla
Vasconcelos, Maria João
Bourrain, Jean Luc
Demoly, Pascal
Chiriac, Anca-Mirela
author_sort Barakat, Leyla
collection PubMed
description Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases. Incidence of drug hypersensitivity reactions (DHRs) to PPIs has been rising, presumably because of their increased consumption. Most DHR are IgE-mediated, with half of the reactions being anaphylactic. We describe the case of a Caucasian 50-year-old female patient referred to our allergy department after 2 episodes of anaphylaxis. The allergy work-up distinguished PPI as a cause of delayed onset (14 hours) and immediate onset (45 minutes) IgE-mediated DHR.
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spelling pubmed-68261112019-11-12 IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset Barakat, Leyla Vasconcelos, Maria João Bourrain, Jean Luc Demoly, Pascal Chiriac, Anca-Mirela Asia Pac Allergy Hypothesis & Experience Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases. Incidence of drug hypersensitivity reactions (DHRs) to PPIs has been rising, presumably because of their increased consumption. Most DHR are IgE-mediated, with half of the reactions being anaphylactic. We describe the case of a Caucasian 50-year-old female patient referred to our allergy department after 2 episodes of anaphylaxis. The allergy work-up distinguished PPI as a cause of delayed onset (14 hours) and immediate onset (45 minutes) IgE-mediated DHR. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2019-10-14 /pmc/articles/PMC6826111/ /pubmed/31720241 http://dx.doi.org/10.5415/apallergy.2019.9.e30 Text en Copyright © 2019. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hypothesis & Experience
Barakat, Leyla
Vasconcelos, Maria João
Bourrain, Jean Luc
Demoly, Pascal
Chiriac, Anca-Mirela
IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset
title IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset
title_full IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset
title_fullStr IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset
title_full_unstemmed IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset
title_short IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset
title_sort ige-mediated allergy to proton pump inhibitors with both delayed and immediate onset
topic Hypothesis & Experience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826111/
https://www.ncbi.nlm.nih.gov/pubmed/31720241
http://dx.doi.org/10.5415/apallergy.2019.9.e30
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AT bourrainjeanluc igemediatedallergytoprotonpumpinhibitorswithbothdelayedandimmediateonset
AT demolypascal igemediatedallergytoprotonpumpinhibitorswithbothdelayedandimmediateonset
AT chiriacancamirela igemediatedallergytoprotonpumpinhibitorswithbothdelayedandimmediateonset

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