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The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age
BACKGROUND: Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship. OBJECTIVE: We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker for exposure to oxidative stress, in early life is assoc...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asia Pacific Association of Allergy, Asthma and Clinical Immunology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826115/ https://www.ncbi.nlm.nih.gov/pubmed/31720244 http://dx.doi.org/10.5415/apallergy.2019.9.e33 |
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author | Suh, Dong In Kang, Mi-Jin Park, Yoon Mee Lee, Jun-Kyu Lee, So-Yeon Sheen, Youn Ho Kim, Kyung Won Ahn, Kangmo Hong, Soo-Jong |
author_facet | Suh, Dong In Kang, Mi-Jin Park, Yoon Mee Lee, Jun-Kyu Lee, So-Yeon Sheen, Youn Ho Kim, Kyung Won Ahn, Kangmo Hong, Soo-Jong |
author_sort | Suh, Dong In |
collection | PubMed |
description | BACKGROUND: Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship. OBJECTIVE: We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker for exposure to oxidative stress, in early life is associated with increased risk of asthma development during the preschool period. METHODS: We assessed the follow-up clinical data of a subgroup from a birth cohort whose LTLs had been measured from cord-blood and 1-year peripheral-blood samples. We examined whether the LTLs would be associated with asthma development at the age of 2–4 years. RESULTS: The data of 84 subjects were analyzed. LTLs were measured from the cord-blood and 1-year peripheral blood of 75 and 79 subjects, respectively. Among them, 14 subjects (16.7%) developed bronchial asthma between 2–4 years old. Prenatally stressed subjects had marginally increased odds of developing asthma (p = 0.097). There was no significant difference in the odds of preschool-asthma development between the groups with shorter and longer cord-blood LTLs (odds ratio [OR], 0.651; 95% confidence interval [CI], 0.184–2.306) or in the odds between the groups with shorter and longer 1-year peripheral-blood LTLs (OR, 0.448; 95% CI, 0.135–1.483). Finally, subjects with both higher prenatal stress and shorter LTLs did not have significantly higher odds of preschool-asthma development (for cord-blood: OR, 1.242; 95% CI, 0.353–4.368; for 1-year peripheral-blood: OR, 1.451; 95% CI, 0.428–4.919). CONCLUSION: There was no significant association between early life LTLs and higher risk of bronchial-asthma development during the preschool years. |
format | Online Article Text |
id | pubmed-6826115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Asia Pacific Association of Allergy, Asthma and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-68261152019-11-12 The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age Suh, Dong In Kang, Mi-Jin Park, Yoon Mee Lee, Jun-Kyu Lee, So-Yeon Sheen, Youn Ho Kim, Kyung Won Ahn, Kangmo Hong, Soo-Jong Asia Pac Allergy Original Article BACKGROUND: Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship. OBJECTIVE: We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker for exposure to oxidative stress, in early life is associated with increased risk of asthma development during the preschool period. METHODS: We assessed the follow-up clinical data of a subgroup from a birth cohort whose LTLs had been measured from cord-blood and 1-year peripheral-blood samples. We examined whether the LTLs would be associated with asthma development at the age of 2–4 years. RESULTS: The data of 84 subjects were analyzed. LTLs were measured from the cord-blood and 1-year peripheral blood of 75 and 79 subjects, respectively. Among them, 14 subjects (16.7%) developed bronchial asthma between 2–4 years old. Prenatally stressed subjects had marginally increased odds of developing asthma (p = 0.097). There was no significant difference in the odds of preschool-asthma development between the groups with shorter and longer cord-blood LTLs (odds ratio [OR], 0.651; 95% confidence interval [CI], 0.184–2.306) or in the odds between the groups with shorter and longer 1-year peripheral-blood LTLs (OR, 0.448; 95% CI, 0.135–1.483). Finally, subjects with both higher prenatal stress and shorter LTLs did not have significantly higher odds of preschool-asthma development (for cord-blood: OR, 1.242; 95% CI, 0.353–4.368; for 1-year peripheral-blood: OR, 1.451; 95% CI, 0.428–4.919). CONCLUSION: There was no significant association between early life LTLs and higher risk of bronchial-asthma development during the preschool years. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2019-10-14 /pmc/articles/PMC6826115/ /pubmed/31720244 http://dx.doi.org/10.5415/apallergy.2019.9.e33 Text en Copyright © 2019. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Suh, Dong In Kang, Mi-Jin Park, Yoon Mee Lee, Jun-Kyu Lee, So-Yeon Sheen, Youn Ho Kim, Kyung Won Ahn, Kangmo Hong, Soo-Jong The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age |
title | The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age |
title_full | The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age |
title_fullStr | The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age |
title_full_unstemmed | The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age |
title_short | The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age |
title_sort | risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826115/ https://www.ncbi.nlm.nih.gov/pubmed/31720244 http://dx.doi.org/10.5415/apallergy.2019.9.e33 |
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