Mitochondrial DNA somatic mutation burden and heteroplasmy are associated with chronological age, smoking, and HIV infection

The gradual accumulation of mitochondrial DNA (mtDNA) mutations is implicated in aging and may contribute to the accelerated aging phenotype seen with tobacco smoking and HIV infection. mtDNA mutations are thought to arise from oxidative damage; however, recent reports implicate polymerase γ errors...

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Detalles Bibliográficos
Autores principales: Ziada, Adam S., Lu, Meng Ying, Ignas‐Menzies, Jarek, Paintsil, Elijah, Li, Min, Ogbuagu, Onyema, Saberi, Sara, Hsieh, Anthony Y. Y., Sattha, Beheroze, Harrigan, P. Richard, Kalloger, Steve, Côté, Hélène C. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826146/
https://www.ncbi.nlm.nih.gov/pubmed/31407474
http://dx.doi.org/10.1111/acel.13018

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