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LOXL 2 Promotes The Epithelial–Mesenchymal Transition And Malignant Progression Of Cervical Cancer

PURPOSE: Increasing evidence suggests that lysyl oxidase-like 2 (LOXL2) contributes to tumor progression. However, the role of LOXL2 in cervical cancer still remains unclear. PATIENTS AND METHODS: We used the TCGA database to analyze the expression of LOXL2 in cervical cancer and its role on surviva...

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Autores principales: Tian, Jing, Sun, He-Xi, Li, Ying-Chun, Jiang, Li, Zhang, Shan-Ling, Hao, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826188/
https://www.ncbi.nlm.nih.gov/pubmed/31802904
http://dx.doi.org/10.2147/OTT.S217794
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author Tian, Jing
Sun, He-Xi
Li, Ying-Chun
Jiang, Li
Zhang, Shan-Ling
Hao, Quan
author_facet Tian, Jing
Sun, He-Xi
Li, Ying-Chun
Jiang, Li
Zhang, Shan-Ling
Hao, Quan
author_sort Tian, Jing
collection PubMed
description PURPOSE: Increasing evidence suggests that lysyl oxidase-like 2 (LOXL2) contributes to tumor progression. However, the role of LOXL2 in cervical cancer still remains unclear. PATIENTS AND METHODS: We used the TCGA database to analyze the expression of LOXL2 in cervical cancer and its role on survival. The effects of LOXL2 on cervical cancer metastasis and EMT were verified by transwell and wound healing assay. Western blot assay was used to detect the effect of LOXL2 on EMT-related gene expression. In addition, we used animal experiments to observe the role of LOXL2 on tumor genesis and metastasis in cervical cancer. RESULTS: Here we found that LOXL2 participates in epithelial–mesenchymal transition-related cervical cancer progression. LOXL2 ablation in cervical cancer cells inhibited cell metastatic ability, whereas LOXL2 overexpression promoted cell metastasis. In addition, more clinical data from TCGA revealed that LOXL2 is closely related to the prognosis and is highly expressed in highly malignant and metastatic cervical tumors. CONCLUSION: Taken together, our findings established a pathophysiologic role and new function for LOXL2 in cervical cancer metastasis.
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spelling pubmed-68261882019-12-04 LOXL 2 Promotes The Epithelial–Mesenchymal Transition And Malignant Progression Of Cervical Cancer Tian, Jing Sun, He-Xi Li, Ying-Chun Jiang, Li Zhang, Shan-Ling Hao, Quan Onco Targets Ther Original Research PURPOSE: Increasing evidence suggests that lysyl oxidase-like 2 (LOXL2) contributes to tumor progression. However, the role of LOXL2 in cervical cancer still remains unclear. PATIENTS AND METHODS: We used the TCGA database to analyze the expression of LOXL2 in cervical cancer and its role on survival. The effects of LOXL2 on cervical cancer metastasis and EMT were verified by transwell and wound healing assay. Western blot assay was used to detect the effect of LOXL2 on EMT-related gene expression. In addition, we used animal experiments to observe the role of LOXL2 on tumor genesis and metastasis in cervical cancer. RESULTS: Here we found that LOXL2 participates in epithelial–mesenchymal transition-related cervical cancer progression. LOXL2 ablation in cervical cancer cells inhibited cell metastatic ability, whereas LOXL2 overexpression promoted cell metastasis. In addition, more clinical data from TCGA revealed that LOXL2 is closely related to the prognosis and is highly expressed in highly malignant and metastatic cervical tumors. CONCLUSION: Taken together, our findings established a pathophysiologic role and new function for LOXL2 in cervical cancer metastasis. Dove 2019-10-30 /pmc/articles/PMC6826188/ /pubmed/31802904 http://dx.doi.org/10.2147/OTT.S217794 Text en © 2019 Tian et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Tian, Jing
Sun, He-Xi
Li, Ying-Chun
Jiang, Li
Zhang, Shan-Ling
Hao, Quan
LOXL 2 Promotes The Epithelial–Mesenchymal Transition And Malignant Progression Of Cervical Cancer
title LOXL 2 Promotes The Epithelial–Mesenchymal Transition And Malignant Progression Of Cervical Cancer
title_full LOXL 2 Promotes The Epithelial–Mesenchymal Transition And Malignant Progression Of Cervical Cancer
title_fullStr LOXL 2 Promotes The Epithelial–Mesenchymal Transition And Malignant Progression Of Cervical Cancer
title_full_unstemmed LOXL 2 Promotes The Epithelial–Mesenchymal Transition And Malignant Progression Of Cervical Cancer
title_short LOXL 2 Promotes The Epithelial–Mesenchymal Transition And Malignant Progression Of Cervical Cancer
title_sort loxl 2 promotes the epithelial–mesenchymal transition and malignant progression of cervical cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826188/
https://www.ncbi.nlm.nih.gov/pubmed/31802904
http://dx.doi.org/10.2147/OTT.S217794
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