Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

DNA repair via homologous recombination (HR) is indispensable for genome integrity and cell survival but if unrestrained can result in undesired chromosomal rearrangements. The regulatory mechanisms of HR are not fully understood. Cyclic GMP‐AMP synthase (cGAS) is best known as a cytosolic innate im...

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Detalles Bibliográficos
Autores principales: Jiang, Hui, Xue, Xiaoyu, Panda, Swarupa, Kawale, Ajinkya, Hooy, Richard M, Liang, Fengshan, Sohn, Jungsan, Sung, Patrick, Gekara, Nelson O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826206/
https://www.ncbi.nlm.nih.gov/pubmed/31544964
http://dx.doi.org/10.15252/embj.2019102718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826206/
https://www.ncbi.nlm.nih.gov/pubmed/31544964
http://dx.doi.org/10.15252/embj.2019102718

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