Perturbation of maternal PIASy abundance disrupts zygotic genome activation and embryonic development via SUMOylation pathway

During the maternal-to-zygotic transition (MZT), mRNAs and proteins stored in oocytes are degraded and zygotic genes are activated. We have previously shown that the ubiquitin-proteasome system (UPS)-mediated degradation of maternal proteins plays a role in the onset of zygotic transcription. Howeve...

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Detalles Bibliográficos
Autores principales: Higuchi, Chika, Yamamoto, Mari, Shin, Seung-Wook, Miyamoto, Kei, Matsumoto, Kazuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826278/
https://www.ncbi.nlm.nih.gov/pubmed/31640975
http://dx.doi.org/10.1242/bio.048652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826278/
https://www.ncbi.nlm.nih.gov/pubmed/31640975
http://dx.doi.org/10.1242/bio.048652

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