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Perturbation of maternal PIASy abundance disrupts zygotic genome activation and embryonic development via SUMOylation pathway
During the maternal-to-zygotic transition (MZT), mRNAs and proteins stored in oocytes are degraded and zygotic genes are activated. We have previously shown that the ubiquitin-proteasome system (UPS)-mediated degradation of maternal proteins plays a role in the onset of zygotic transcription. Howeve...
Autores principales: | Higuchi, Chika, Yamamoto, Mari, Shin, Seung-Wook, Miyamoto, Kei, Matsumoto, Kazuya |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826278/ https://www.ncbi.nlm.nih.gov/pubmed/31640975 http://dx.doi.org/10.1242/bio.048652 |
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