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Heterogeneous beta-catenin activation is sufficient to cause hepatocellular carcinoma in zebrafish

Up to 41% of hepatocellular carcinomas (HCCs) result from activating mutations in the CTNNB1 gene encoding β-catenin. HCC-associated CTNNB1 mutations stabilize the β-catenin protein, leading to nuclear and/or cytoplasmic localization of β-catenin and downstream activation of Wnt target genes. In pat...

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Detalles Bibliográficos
Autores principales:	Kalasekar, Sharanya M., Kotiyal, Srishti, Conley, Christopher, Phan, Cindy, Young, Annika, Evason, Kimberley J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826293/ https://www.ncbi.nlm.nih.gov/pubmed/31575545 http://dx.doi.org/10.1242/bio.047829

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