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Outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to raw drinking milk resolved by rapid application of advanced pathogen characterisation methods, England, August to October 2017

An outbreak of Shiga toxin-producing Escherichia coli (STEC) O157:H7 occurred on the Isle of Wight between August and October 2017. Of the seven cases linked to the outbreak, five were identified through the statutory notification process and two were identified through national surveillance of whol...

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Autores principales: Treacy, Juli, Jenkins, Claire, Paranthaman, Karthik, Jorgensen, Frieda, Mueller-Doblies, Doris, Anjum, Muna, Kaindama, Lukeki, Hartman, Hassan, Kirchner, Miranda, Carson, Therese, Kar-Purkayastha, Ishani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826345/
https://www.ncbi.nlm.nih.gov/pubmed/31014418
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.16.1800191
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author Treacy, Juli
Jenkins, Claire
Paranthaman, Karthik
Jorgensen, Frieda
Mueller-Doblies, Doris
Anjum, Muna
Kaindama, Lukeki
Hartman, Hassan
Kirchner, Miranda
Carson, Therese
Kar-Purkayastha, Ishani
author_facet Treacy, Juli
Jenkins, Claire
Paranthaman, Karthik
Jorgensen, Frieda
Mueller-Doblies, Doris
Anjum, Muna
Kaindama, Lukeki
Hartman, Hassan
Kirchner, Miranda
Carson, Therese
Kar-Purkayastha, Ishani
author_sort Treacy, Juli
collection PubMed
description An outbreak of Shiga toxin-producing Escherichia coli (STEC) O157:H7 occurred on the Isle of Wight between August and October 2017. Of the seven cases linked to the outbreak, five were identified through the statutory notification process and two were identified through national surveillance of whole genome sequencing data. Enhanced surveillance questionnaires established a common link to a farm, and link to the likely food vehicle, raw drinking milk (RDM). Microbiological investigations, including PCR, identified the presence of STEC O157:H7 in samples of RDM. Analysis of core genome single nucleotide polymorphism (SNP) data of STEC O157:H7 from human stool specimens, animal faecal samples and RDM demonstrated a one SNP difference between isolates, and therefore close genetic relatedness. Control measures that were put in place included suspension of sales and recall of RDM, as well as restrictions on public access to parts of the farm. Successful integration of traditional epidemiological surveillance and advanced laboratory methods for the detection and characterisation of STEC O157:H7 from human, animal and environmental samples enabled prompt identification of the outbreak vehicle and provided evidence to support the outbreak control team’s decision-making, leading to implementation of effective control measures in a timely manner.
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spelling pubmed-68263452019-11-14 Outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to raw drinking milk resolved by rapid application of advanced pathogen characterisation methods, England, August to October 2017 Treacy, Juli Jenkins, Claire Paranthaman, Karthik Jorgensen, Frieda Mueller-Doblies, Doris Anjum, Muna Kaindama, Lukeki Hartman, Hassan Kirchner, Miranda Carson, Therese Kar-Purkayastha, Ishani Euro Surveill Outbreaks An outbreak of Shiga toxin-producing Escherichia coli (STEC) O157:H7 occurred on the Isle of Wight between August and October 2017. Of the seven cases linked to the outbreak, five were identified through the statutory notification process and two were identified through national surveillance of whole genome sequencing data. Enhanced surveillance questionnaires established a common link to a farm, and link to the likely food vehicle, raw drinking milk (RDM). Microbiological investigations, including PCR, identified the presence of STEC O157:H7 in samples of RDM. Analysis of core genome single nucleotide polymorphism (SNP) data of STEC O157:H7 from human stool specimens, animal faecal samples and RDM demonstrated a one SNP difference between isolates, and therefore close genetic relatedness. Control measures that were put in place included suspension of sales and recall of RDM, as well as restrictions on public access to parts of the farm. Successful integration of traditional epidemiological surveillance and advanced laboratory methods for the detection and characterisation of STEC O157:H7 from human, animal and environmental samples enabled prompt identification of the outbreak vehicle and provided evidence to support the outbreak control team’s decision-making, leading to implementation of effective control measures in a timely manner. European Centre for Disease Prevention and Control (ECDC) 2019-04-18 /pmc/articles/PMC6826345/ /pubmed/31014418 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.16.1800191 Text en This article is copyright of the authors or their affiliated institutions, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Outbreaks
Treacy, Juli
Jenkins, Claire
Paranthaman, Karthik
Jorgensen, Frieda
Mueller-Doblies, Doris
Anjum, Muna
Kaindama, Lukeki
Hartman, Hassan
Kirchner, Miranda
Carson, Therese
Kar-Purkayastha, Ishani
Outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to raw drinking milk resolved by rapid application of advanced pathogen characterisation methods, England, August to October 2017
title Outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to raw drinking milk resolved by rapid application of advanced pathogen characterisation methods, England, August to October 2017
title_full Outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to raw drinking milk resolved by rapid application of advanced pathogen characterisation methods, England, August to October 2017
title_fullStr Outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to raw drinking milk resolved by rapid application of advanced pathogen characterisation methods, England, August to October 2017
title_full_unstemmed Outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to raw drinking milk resolved by rapid application of advanced pathogen characterisation methods, England, August to October 2017
title_short Outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to raw drinking milk resolved by rapid application of advanced pathogen characterisation methods, England, August to October 2017
title_sort outbreak of shiga toxin-producing escherichia coli o157:h7 linked to raw drinking milk resolved by rapid application of advanced pathogen characterisation methods, england, august to october 2017
topic Outbreaks
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826345/
https://www.ncbi.nlm.nih.gov/pubmed/31014418
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.16.1800191
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