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Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients
In recent years, an increasing number of studies have shown that elevated expression of cyclin dependent kinase (Cdk5) contributes to the oncogenic initiation and progression of many types of cancers. In this study, we investigated the expression pattern of Cdk5 in colorectal cancer (CRC) cell lines...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826373/ https://www.ncbi.nlm.nih.gov/pubmed/31614664 http://dx.doi.org/10.3390/cancers11101540 |
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author | Ruiz de Porras, Vicenç Bystrup, Sara Cabrero-de las Heras, Sara Musulén, Eva Palomero, Luis Alonso, Maria Henar Nieto, Rocio Arango, Diego Moreno, Víctor Queralt, Cristina Manzano, José Luis Layos, Laura Bugés, Cristina Martinez-Balibrea, Eva |
author_facet | Ruiz de Porras, Vicenç Bystrup, Sara Cabrero-de las Heras, Sara Musulén, Eva Palomero, Luis Alonso, Maria Henar Nieto, Rocio Arango, Diego Moreno, Víctor Queralt, Cristina Manzano, José Luis Layos, Laura Bugés, Cristina Martinez-Balibrea, Eva |
author_sort | Ruiz de Porras, Vicenç |
collection | PubMed |
description | In recent years, an increasing number of studies have shown that elevated expression of cyclin dependent kinase (Cdk5) contributes to the oncogenic initiation and progression of many types of cancers. In this study, we investigated the expression pattern of Cdk5 in colorectal cancer (CRC) cell lines and in a large number of tumor samples in order to evaluate its relevance in this pathogenesis and possible use as a prognostic marker. We found that Cdk5 is highly expressed and activated in CRC cell lines and that silencing of the kinase decreases their migration ability. In tumor tissues, Cdk5 is overexpressed compared to normal tissues due to a copy number gain. In patients with localized disease, we found that high Cdk5 levels correlate with poor prognosis, while in the metastatic setting, this was only the case for patients receiving an oxaliplatin-based treatment. When exploring the Cdk5 levels in the consensus molecular subtypes (CMS), we found the lowest levels in subtype 1, where high Cdk5 again was associated with a poorer prognosis. In conclusion, we confirm that Cdk5 is involved in CRC and disease progression and that it could serve as a prognostic and predictive biomarker in this disease. |
format | Online Article Text |
id | pubmed-6826373 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68263732019-11-18 Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients Ruiz de Porras, Vicenç Bystrup, Sara Cabrero-de las Heras, Sara Musulén, Eva Palomero, Luis Alonso, Maria Henar Nieto, Rocio Arango, Diego Moreno, Víctor Queralt, Cristina Manzano, José Luis Layos, Laura Bugés, Cristina Martinez-Balibrea, Eva Cancers (Basel) Article In recent years, an increasing number of studies have shown that elevated expression of cyclin dependent kinase (Cdk5) contributes to the oncogenic initiation and progression of many types of cancers. In this study, we investigated the expression pattern of Cdk5 in colorectal cancer (CRC) cell lines and in a large number of tumor samples in order to evaluate its relevance in this pathogenesis and possible use as a prognostic marker. We found that Cdk5 is highly expressed and activated in CRC cell lines and that silencing of the kinase decreases their migration ability. In tumor tissues, Cdk5 is overexpressed compared to normal tissues due to a copy number gain. In patients with localized disease, we found that high Cdk5 levels correlate with poor prognosis, while in the metastatic setting, this was only the case for patients receiving an oxaliplatin-based treatment. When exploring the Cdk5 levels in the consensus molecular subtypes (CMS), we found the lowest levels in subtype 1, where high Cdk5 again was associated with a poorer prognosis. In conclusion, we confirm that Cdk5 is involved in CRC and disease progression and that it could serve as a prognostic and predictive biomarker in this disease. MDPI 2019-10-11 /pmc/articles/PMC6826373/ /pubmed/31614664 http://dx.doi.org/10.3390/cancers11101540 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ruiz de Porras, Vicenç Bystrup, Sara Cabrero-de las Heras, Sara Musulén, Eva Palomero, Luis Alonso, Maria Henar Nieto, Rocio Arango, Diego Moreno, Víctor Queralt, Cristina Manzano, José Luis Layos, Laura Bugés, Cristina Martinez-Balibrea, Eva Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients |
title | Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients |
title_full | Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients |
title_fullStr | Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients |
title_full_unstemmed | Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients |
title_short | Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients |
title_sort | tumor expression of cyclin-dependent kinase 5 (cdk5) is a prognostic biomarker and predicts outcome of oxaliplatin-treated metastatic colorectal cancer patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826373/ https://www.ncbi.nlm.nih.gov/pubmed/31614664 http://dx.doi.org/10.3390/cancers11101540 |
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