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A Portal to Visualize Transcriptome Profiles in Mouse Models of Neurological Disorders

Target nomination for drug development has been a major challenge in the path to finding a cure for several neurological disorders. Comprehensive transcriptome profiles have revealed brain gene expression changes associated with many neurological disorders, and the functional validation of these cha...

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Autores principales: Al-Ouran, Rami, Wan, Ying-Wooi, Mangleburg, Carl Grant, Lee, Tom V., Allison, Katherine, Shulman, Joshua M., Liu, Zhandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826490/
https://www.ncbi.nlm.nih.gov/pubmed/31561642
http://dx.doi.org/10.3390/genes10100759
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author Al-Ouran, Rami
Wan, Ying-Wooi
Mangleburg, Carl Grant
Lee, Tom V.
Allison, Katherine
Shulman, Joshua M.
Liu, Zhandong
author_facet Al-Ouran, Rami
Wan, Ying-Wooi
Mangleburg, Carl Grant
Lee, Tom V.
Allison, Katherine
Shulman, Joshua M.
Liu, Zhandong
author_sort Al-Ouran, Rami
collection PubMed
description Target nomination for drug development has been a major challenge in the path to finding a cure for several neurological disorders. Comprehensive transcriptome profiles have revealed brain gene expression changes associated with many neurological disorders, and the functional validation of these changes is a critical next step. Model organisms are a proven approach for the elucidation of disease mechanisms, including screening of gene candidates as therapeutic targets. Frequently, multiple models exist for a given disease, creating a challenge to select the optimal model for validation and functional follow-up. To help in nominating the best mouse models for studying neurological diseases, we developed a web portal to visualize mouse transcriptomic data related to neurological disorders. Users can examine gene expression changes across mouse model studies to help select the optimal mouse model for further investigation. The portal provides access to mouse studies related to Alzheimer’s diseases (AD), Parkinson’s disease (PD), Huntington’s disease (HD), Amyotrophic Lateral Sclerosis (ALS), Spinocerebellar ataxia (SCA), and models related to aging.
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spelling pubmed-68264902019-11-18 A Portal to Visualize Transcriptome Profiles in Mouse Models of Neurological Disorders Al-Ouran, Rami Wan, Ying-Wooi Mangleburg, Carl Grant Lee, Tom V. Allison, Katherine Shulman, Joshua M. Liu, Zhandong Genes (Basel) Article Target nomination for drug development has been a major challenge in the path to finding a cure for several neurological disorders. Comprehensive transcriptome profiles have revealed brain gene expression changes associated with many neurological disorders, and the functional validation of these changes is a critical next step. Model organisms are a proven approach for the elucidation of disease mechanisms, including screening of gene candidates as therapeutic targets. Frequently, multiple models exist for a given disease, creating a challenge to select the optimal model for validation and functional follow-up. To help in nominating the best mouse models for studying neurological diseases, we developed a web portal to visualize mouse transcriptomic data related to neurological disorders. Users can examine gene expression changes across mouse model studies to help select the optimal mouse model for further investigation. The portal provides access to mouse studies related to Alzheimer’s diseases (AD), Parkinson’s disease (PD), Huntington’s disease (HD), Amyotrophic Lateral Sclerosis (ALS), Spinocerebellar ataxia (SCA), and models related to aging. MDPI 2019-09-26 /pmc/articles/PMC6826490/ /pubmed/31561642 http://dx.doi.org/10.3390/genes10100759 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Al-Ouran, Rami
Wan, Ying-Wooi
Mangleburg, Carl Grant
Lee, Tom V.
Allison, Katherine
Shulman, Joshua M.
Liu, Zhandong
A Portal to Visualize Transcriptome Profiles in Mouse Models of Neurological Disorders
title A Portal to Visualize Transcriptome Profiles in Mouse Models of Neurological Disorders
title_full A Portal to Visualize Transcriptome Profiles in Mouse Models of Neurological Disorders
title_fullStr A Portal to Visualize Transcriptome Profiles in Mouse Models of Neurological Disorders
title_full_unstemmed A Portal to Visualize Transcriptome Profiles in Mouse Models of Neurological Disorders
title_short A Portal to Visualize Transcriptome Profiles in Mouse Models of Neurological Disorders
title_sort portal to visualize transcriptome profiles in mouse models of neurological disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826490/
https://www.ncbi.nlm.nih.gov/pubmed/31561642
http://dx.doi.org/10.3390/genes10100759
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