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Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population

SIMPLE SUMMARY: Reproductive traits are economically important in the pig industry, and it is critical to explore their underlying genetic architecture. Hence, four reproductive traits, including litter size at birth (LSB), litter weight at birth (LWB), litter size at weaning (LSW), and litter weigh...

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Detalles Bibliográficos
Autores principales: Zhang, Zhe, Chen, Zitao, Ye, Shaopan, He, Yingting, Huang, Shuwen, Yuan, Xiaolong, Chen, Zanmou, Zhang, Hao, Li, Jiaqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826494/
https://www.ncbi.nlm.nih.gov/pubmed/31561612
http://dx.doi.org/10.3390/ani9100732
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author Zhang, Zhe
Chen, Zitao
Ye, Shaopan
He, Yingting
Huang, Shuwen
Yuan, Xiaolong
Chen, Zanmou
Zhang, Hao
Li, Jiaqi
author_facet Zhang, Zhe
Chen, Zitao
Ye, Shaopan
He, Yingting
Huang, Shuwen
Yuan, Xiaolong
Chen, Zanmou
Zhang, Hao
Li, Jiaqi
author_sort Zhang, Zhe
collection PubMed
description SIMPLE SUMMARY: Reproductive traits are economically important in the pig industry, and it is critical to explore their underlying genetic architecture. Hence, four reproductive traits, including litter size at birth (LSB), litter weight at birth (LWB), litter size at weaning (LSW), and litter weight at weaning (LWW), were examined. Through a genome-wide association study in a Duroc pig herd, several candidate single-nucleotide polymorphisms (SNPs) and genes were found potentially associated with the traits of interest. These findings help to understand the genetic basis of porcine reproductive traits and could be applied in pig breeding programs. ABSTRACT: In the pig industry, reproductive traits constantly influence the production efficiency. To identify markers and candidate genes underlying porcine reproductive traits, a genome-wide association study (GWAS) was performed in a Duroc pig population. In total, 1067 pigs were genotyped using single-nucleotide polymorphism (SNP) chips, and four reproductive traits, including litter size at birth (LSB), litter weight at birth (LWB), litter size at weaning (LSW), and litter weight at weaning (LWW), were examined. The results showed that 20 potential SNPs reached the level of suggestive significance and were associated with these traits of interest. Several important candidate genes, including TXN2, KCNA1, ENSSSCG00000003546, ZDHHC18, MAP2K6, BICC1, FAM135B, EPHB2, SEMA4D, ST3GAL1, KCTD3, FAM110A, TMEM132D, TBX3, and FAM110A, were identified and might compose the underlying genetic architecture of porcine reproductive traits. These findings help to understand the genetic basis of porcine reproductive traits and provide important information for molecular breeding in pigs.
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spelling pubmed-68264942019-11-18 Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population Zhang, Zhe Chen, Zitao Ye, Shaopan He, Yingting Huang, Shuwen Yuan, Xiaolong Chen, Zanmou Zhang, Hao Li, Jiaqi Animals (Basel) Article SIMPLE SUMMARY: Reproductive traits are economically important in the pig industry, and it is critical to explore their underlying genetic architecture. Hence, four reproductive traits, including litter size at birth (LSB), litter weight at birth (LWB), litter size at weaning (LSW), and litter weight at weaning (LWW), were examined. Through a genome-wide association study in a Duroc pig herd, several candidate single-nucleotide polymorphisms (SNPs) and genes were found potentially associated with the traits of interest. These findings help to understand the genetic basis of porcine reproductive traits and could be applied in pig breeding programs. ABSTRACT: In the pig industry, reproductive traits constantly influence the production efficiency. To identify markers and candidate genes underlying porcine reproductive traits, a genome-wide association study (GWAS) was performed in a Duroc pig population. In total, 1067 pigs were genotyped using single-nucleotide polymorphism (SNP) chips, and four reproductive traits, including litter size at birth (LSB), litter weight at birth (LWB), litter size at weaning (LSW), and litter weight at weaning (LWW), were examined. The results showed that 20 potential SNPs reached the level of suggestive significance and were associated with these traits of interest. Several important candidate genes, including TXN2, KCNA1, ENSSSCG00000003546, ZDHHC18, MAP2K6, BICC1, FAM135B, EPHB2, SEMA4D, ST3GAL1, KCTD3, FAM110A, TMEM132D, TBX3, and FAM110A, were identified and might compose the underlying genetic architecture of porcine reproductive traits. These findings help to understand the genetic basis of porcine reproductive traits and provide important information for molecular breeding in pigs. MDPI 2019-09-26 /pmc/articles/PMC6826494/ /pubmed/31561612 http://dx.doi.org/10.3390/ani9100732 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Zhe
Chen, Zitao
Ye, Shaopan
He, Yingting
Huang, Shuwen
Yuan, Xiaolong
Chen, Zanmou
Zhang, Hao
Li, Jiaqi
Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population
title Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population
title_full Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population
title_fullStr Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population
title_full_unstemmed Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population
title_short Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population
title_sort genome-wide association study for reproductive traits in a duroc pig population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826494/
https://www.ncbi.nlm.nih.gov/pubmed/31561612
http://dx.doi.org/10.3390/ani9100732
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