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Tumor Endothelial Heterogeneity in Cancer Progression

Tumor blood vessels supply nutrients and oxygen to tumor cells for their growth and provide routes for them to enter circulation. Thus, angiogenesis, the formation of new blood vessels, is essential for tumor progression and metastasis. Tumor endothelial cells (TECs) that cover the inner surfaces of...

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Autores principales: Maishi, Nako, Annan, Dorcas A., Kikuchi, Hiroshi, Hida, Yasuhiro, Hida, Kyoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826555/
https://www.ncbi.nlm.nih.gov/pubmed/31600937
http://dx.doi.org/10.3390/cancers11101511
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author Maishi, Nako
Annan, Dorcas A.
Kikuchi, Hiroshi
Hida, Yasuhiro
Hida, Kyoko
author_facet Maishi, Nako
Annan, Dorcas A.
Kikuchi, Hiroshi
Hida, Yasuhiro
Hida, Kyoko
author_sort Maishi, Nako
collection PubMed
description Tumor blood vessels supply nutrients and oxygen to tumor cells for their growth and provide routes for them to enter circulation. Thus, angiogenesis, the formation of new blood vessels, is essential for tumor progression and metastasis. Tumor endothelial cells (TECs) that cover the inner surfaces of tumor blood vessels reportedly show phenotypes distinct from those of their normal counterparts. As examples, TECs show cytogenetic abnormalities, resistance to anticancer drugs, activated proliferation and migration, and specific gene expression patterns. TECs contain stem-like cell populations, which means that the origin of TECs is heterogeneous. In addition, since some abnormal phenotypes in TECs are induced by factors in the tumor microenvironment, such as hypoxia and tumor cell-derived factors, phenotypic diversity in TECs may be caused in part by intratumoral heterogeneity. Recent studies have identified that the interaction of tumor cells and TECs by juxtacrine and paracrine signaling contributes to tumor malignancy. Understanding TEC abnormality and heterogeneity is important for treatment of cancers. This review provides an overview of the diversity of TECs and discusses the interaction between TECs and tumor cells in the tumor microenvironment.
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spelling pubmed-68265552019-11-18 Tumor Endothelial Heterogeneity in Cancer Progression Maishi, Nako Annan, Dorcas A. Kikuchi, Hiroshi Hida, Yasuhiro Hida, Kyoko Cancers (Basel) Review Tumor blood vessels supply nutrients and oxygen to tumor cells for their growth and provide routes for them to enter circulation. Thus, angiogenesis, the formation of new blood vessels, is essential for tumor progression and metastasis. Tumor endothelial cells (TECs) that cover the inner surfaces of tumor blood vessels reportedly show phenotypes distinct from those of their normal counterparts. As examples, TECs show cytogenetic abnormalities, resistance to anticancer drugs, activated proliferation and migration, and specific gene expression patterns. TECs contain stem-like cell populations, which means that the origin of TECs is heterogeneous. In addition, since some abnormal phenotypes in TECs are induced by factors in the tumor microenvironment, such as hypoxia and tumor cell-derived factors, phenotypic diversity in TECs may be caused in part by intratumoral heterogeneity. Recent studies have identified that the interaction of tumor cells and TECs by juxtacrine and paracrine signaling contributes to tumor malignancy. Understanding TEC abnormality and heterogeneity is important for treatment of cancers. This review provides an overview of the diversity of TECs and discusses the interaction between TECs and tumor cells in the tumor microenvironment. MDPI 2019-10-09 /pmc/articles/PMC6826555/ /pubmed/31600937 http://dx.doi.org/10.3390/cancers11101511 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Maishi, Nako
Annan, Dorcas A.
Kikuchi, Hiroshi
Hida, Yasuhiro
Hida, Kyoko
Tumor Endothelial Heterogeneity in Cancer Progression
title Tumor Endothelial Heterogeneity in Cancer Progression
title_full Tumor Endothelial Heterogeneity in Cancer Progression
title_fullStr Tumor Endothelial Heterogeneity in Cancer Progression
title_full_unstemmed Tumor Endothelial Heterogeneity in Cancer Progression
title_short Tumor Endothelial Heterogeneity in Cancer Progression
title_sort tumor endothelial heterogeneity in cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826555/
https://www.ncbi.nlm.nih.gov/pubmed/31600937
http://dx.doi.org/10.3390/cancers11101511
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