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Corneal thickness and endothelial cell density in children with type 1 diabetes mellitus
BACKGROUND: The aim of this study was to detect the effect of diabetes on the corneal endothelium in patients of Type 1 diabetes in the pediatric age group and to compare them with age-matched controls. Further, it was proposed to establish any correlation between these changes and risk factors of d...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826602/ https://www.ncbi.nlm.nih.gov/pubmed/31902995 http://dx.doi.org/10.4103/ojo.OJO_21_2018 |
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author | Fernandes, Sheldon Ignatius Nagpal, Shubha |
author_facet | Fernandes, Sheldon Ignatius Nagpal, Shubha |
author_sort | Fernandes, Sheldon Ignatius |
collection | PubMed |
description | BACKGROUND: The aim of this study was to detect the effect of diabetes on the corneal endothelium in patients of Type 1 diabetes in the pediatric age group and to compare them with age-matched controls. Further, it was proposed to establish any correlation between these changes and risk factors of diabetes, viz., age, duration of diabetes, and hemoglobin A1c (HbA1c) values. MATERIALS AND METHODS: This was a prospective cross-sectional study. Fifty children with Type 1 diabetes, between the ages of 7 and 17 years (average, 12.16 ± 2.63 years), and fifty healthy age-matched controls (average 12.28- ±3.00 years) were examined. The central corneal thickness (CCT) and endothelial cell density (CD) were assessed by the Topcon SP-1P specular microscope. The duration of diabetes (average, 3.91 ± 1.65 years) and the HbA1c values (average, 10.92 ± 2.28) were also noted. RESULTS: The average CCT in the diabetics was 525.16 ± 33.14 μ and in the controls 513.44 ± 29.46 μ. This was significantly higher (P = 0.015). The average endothelial CD in the diabetics was 3039.64 ± 292.84 cells/mm(2) and in the nondiabetics 3360.41 ± 268.04 cells/mm(2). This was significantly lower (P < 0.001). A significant correlation was found between the endothelial CD and age of the diabetic patients (P = 0.008). However, there was no significant correlation between the endothelial CD and the CCT with either duration of diabetes or HbA1c. CONCLUSIONS: A significant decrease in the endothelial CD and increase in the CCT occurs in children and adolescents with Type 1 diabetes. With the age of the diabetic patients, the endothelial CD significantly reduces. However, duration of diabetes and HbA1c do not affect these values. |
format | Online Article Text |
id | pubmed-6826602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-68266022020-01-03 Corneal thickness and endothelial cell density in children with type 1 diabetes mellitus Fernandes, Sheldon Ignatius Nagpal, Shubha Oman J Ophthalmol Original Article BACKGROUND: The aim of this study was to detect the effect of diabetes on the corneal endothelium in patients of Type 1 diabetes in the pediatric age group and to compare them with age-matched controls. Further, it was proposed to establish any correlation between these changes and risk factors of diabetes, viz., age, duration of diabetes, and hemoglobin A1c (HbA1c) values. MATERIALS AND METHODS: This was a prospective cross-sectional study. Fifty children with Type 1 diabetes, between the ages of 7 and 17 years (average, 12.16 ± 2.63 years), and fifty healthy age-matched controls (average 12.28- ±3.00 years) were examined. The central corneal thickness (CCT) and endothelial cell density (CD) were assessed by the Topcon SP-1P specular microscope. The duration of diabetes (average, 3.91 ± 1.65 years) and the HbA1c values (average, 10.92 ± 2.28) were also noted. RESULTS: The average CCT in the diabetics was 525.16 ± 33.14 μ and in the controls 513.44 ± 29.46 μ. This was significantly higher (P = 0.015). The average endothelial CD in the diabetics was 3039.64 ± 292.84 cells/mm(2) and in the nondiabetics 3360.41 ± 268.04 cells/mm(2). This was significantly lower (P < 0.001). A significant correlation was found between the endothelial CD and age of the diabetic patients (P = 0.008). However, there was no significant correlation between the endothelial CD and the CCT with either duration of diabetes or HbA1c. CONCLUSIONS: A significant decrease in the endothelial CD and increase in the CCT occurs in children and adolescents with Type 1 diabetes. With the age of the diabetic patients, the endothelial CD significantly reduces. However, duration of diabetes and HbA1c do not affect these values. Wolters Kluwer - Medknow 2019-10-11 /pmc/articles/PMC6826602/ /pubmed/31902995 http://dx.doi.org/10.4103/ojo.OJO_21_2018 Text en Copyright: © 2019 Oman Ophthalmic Society http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Fernandes, Sheldon Ignatius Nagpal, Shubha Corneal thickness and endothelial cell density in children with type 1 diabetes mellitus |
title | Corneal thickness and endothelial cell density in children with type 1 diabetes mellitus |
title_full | Corneal thickness and endothelial cell density in children with type 1 diabetes mellitus |
title_fullStr | Corneal thickness and endothelial cell density in children with type 1 diabetes mellitus |
title_full_unstemmed | Corneal thickness and endothelial cell density in children with type 1 diabetes mellitus |
title_short | Corneal thickness and endothelial cell density in children with type 1 diabetes mellitus |
title_sort | corneal thickness and endothelial cell density in children with type 1 diabetes mellitus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826602/ https://www.ncbi.nlm.nih.gov/pubmed/31902995 http://dx.doi.org/10.4103/ojo.OJO_21_2018 |
work_keys_str_mv | AT fernandessheldonignatius cornealthicknessandendothelialcelldensityinchildrenwithtype1diabetesmellitus AT nagpalshubha cornealthicknessandendothelialcelldensityinchildrenwithtype1diabetesmellitus |