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Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus

Weight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders. In this study, we investigated weight changes after deep brain stimulation of the ve...

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Autores principales: Baldermann, Juan Carlos, Hahn, Lisa, Dembek, Till A., Kohl, Sina, Kuhn, Jens, Visser-Vandewalle, Veerle, Horn, Andreas, Huys, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826646/
https://www.ncbi.nlm.nih.gov/pubmed/31623328
http://dx.doi.org/10.3390/brainsci9100264
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author Baldermann, Juan Carlos
Hahn, Lisa
Dembek, Till A.
Kohl, Sina
Kuhn, Jens
Visser-Vandewalle, Veerle
Horn, Andreas
Huys, Daniel
author_facet Baldermann, Juan Carlos
Hahn, Lisa
Dembek, Till A.
Kohl, Sina
Kuhn, Jens
Visser-Vandewalle, Veerle
Horn, Andreas
Huys, Daniel
author_sort Baldermann, Juan Carlos
collection PubMed
description Weight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders. In this study, we investigated weight changes after deep brain stimulation of the ventral striatum/ventral capsule and to what extent changes are associated with connectivity to feeding-related networks. We retrospectively analyzed 25 patients undergoing deep brain stimulation for obsessive-compulsive disorder or substance dependency. Weight changes were assessed preoperatively and six to twelve months after surgery and then matched with individual stimulation sites and stimulation-dependent functional connectivity to a priori defined regions of interest that are involved in food intake. We observed a significant weight gain after six to twelve months of continuous stimulation. Weight increases were associated with medial/apical localization of stimulation sites and with connectivity to hypothalamic areas and the bed nucleus. Thus, deep brain stimulation of the ventral striatum/ventral capsule influences weight depending on localization and connectivity of stimulation sites. Bearing in mind the significance of weight-related disorders, we advocate further prospective studies investigating the neuroanatomical and neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential.
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spelling pubmed-68266462019-11-18 Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus Baldermann, Juan Carlos Hahn, Lisa Dembek, Till A. Kohl, Sina Kuhn, Jens Visser-Vandewalle, Veerle Horn, Andreas Huys, Daniel Brain Sci Article Weight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders. In this study, we investigated weight changes after deep brain stimulation of the ventral striatum/ventral capsule and to what extent changes are associated with connectivity to feeding-related networks. We retrospectively analyzed 25 patients undergoing deep brain stimulation for obsessive-compulsive disorder or substance dependency. Weight changes were assessed preoperatively and six to twelve months after surgery and then matched with individual stimulation sites and stimulation-dependent functional connectivity to a priori defined regions of interest that are involved in food intake. We observed a significant weight gain after six to twelve months of continuous stimulation. Weight increases were associated with medial/apical localization of stimulation sites and with connectivity to hypothalamic areas and the bed nucleus. Thus, deep brain stimulation of the ventral striatum/ventral capsule influences weight depending on localization and connectivity of stimulation sites. Bearing in mind the significance of weight-related disorders, we advocate further prospective studies investigating the neuroanatomical and neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential. MDPI 2019-10-03 /pmc/articles/PMC6826646/ /pubmed/31623328 http://dx.doi.org/10.3390/brainsci9100264 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baldermann, Juan Carlos
Hahn, Lisa
Dembek, Till A.
Kohl, Sina
Kuhn, Jens
Visser-Vandewalle, Veerle
Horn, Andreas
Huys, Daniel
Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus
title Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus
title_full Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus
title_fullStr Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus
title_full_unstemmed Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus
title_short Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus
title_sort weight change after striatal/capsule deep brain stimulation relates to connectivity to the bed nucleus of the stria terminalis and hypothalamus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826646/
https://www.ncbi.nlm.nih.gov/pubmed/31623328
http://dx.doi.org/10.3390/brainsci9100264
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