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The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury

Mitochondria play a critical role in maintaining cellular function by ATP production. They are also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of mitochondria has been established in many aspects of cell physiology/pathophysiology, including cell signaling. Mitochon...

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Autores principales: Kuznetsov, Andrey V., Javadov, Sabzali, Margreiter, Raimund, Grimm, Michael, Hagenbuchner, Judith, Ausserlechner, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826663/
https://www.ncbi.nlm.nih.gov/pubmed/31590423
http://dx.doi.org/10.3390/antiox8100454
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author Kuznetsov, Andrey V.
Javadov, Sabzali
Margreiter, Raimund
Grimm, Michael
Hagenbuchner, Judith
Ausserlechner, Michael J.
author_facet Kuznetsov, Andrey V.
Javadov, Sabzali
Margreiter, Raimund
Grimm, Michael
Hagenbuchner, Judith
Ausserlechner, Michael J.
author_sort Kuznetsov, Andrey V.
collection PubMed
description Mitochondria play a critical role in maintaining cellular function by ATP production. They are also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of mitochondria has been established in many aspects of cell physiology/pathophysiology, including cell signaling. Mitochondria may deteriorate under various pathological conditions, including ischemia-reperfusion (IR) injury. Mitochondrial injury can be one of the main causes for cardiac and other tissue injuries by energy stress and overproduction of toxic reactive oxygen species, leading to oxidative stress, elevated calcium and apoptotic and necrotic cell death. However, the interplay among these processes in normal and pathological conditions is still poorly understood. Mitochondria play a critical role in cardiac IR injury, where they are directly involved in several pathophysiological mechanisms. We also discuss the role of mitochondria in the context of mitochondrial dynamics, specializations and heterogeneity. Also, we wanted to stress the existence of morphologically and functionally different mitochondrial subpopulations in the heart that may have different sensitivities to diseases and IR injury. Therefore, various cardioprotective interventions that modulate mitochondrial stability, dynamics and turnover, including various pharmacologic agents, specific mitochondrial antioxidants and uncouplers, and ischemic preconditioning can be considered as the main strategies to protect mitochondrial and cardiovascular function and thus enhance longevity.
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spelling pubmed-68266632019-11-18 The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury Kuznetsov, Andrey V. Javadov, Sabzali Margreiter, Raimund Grimm, Michael Hagenbuchner, Judith Ausserlechner, Michael J. Antioxidants (Basel) Review Mitochondria play a critical role in maintaining cellular function by ATP production. They are also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of mitochondria has been established in many aspects of cell physiology/pathophysiology, including cell signaling. Mitochondria may deteriorate under various pathological conditions, including ischemia-reperfusion (IR) injury. Mitochondrial injury can be one of the main causes for cardiac and other tissue injuries by energy stress and overproduction of toxic reactive oxygen species, leading to oxidative stress, elevated calcium and apoptotic and necrotic cell death. However, the interplay among these processes in normal and pathological conditions is still poorly understood. Mitochondria play a critical role in cardiac IR injury, where they are directly involved in several pathophysiological mechanisms. We also discuss the role of mitochondria in the context of mitochondrial dynamics, specializations and heterogeneity. Also, we wanted to stress the existence of morphologically and functionally different mitochondrial subpopulations in the heart that may have different sensitivities to diseases and IR injury. Therefore, various cardioprotective interventions that modulate mitochondrial stability, dynamics and turnover, including various pharmacologic agents, specific mitochondrial antioxidants and uncouplers, and ischemic preconditioning can be considered as the main strategies to protect mitochondrial and cardiovascular function and thus enhance longevity. MDPI 2019-10-06 /pmc/articles/PMC6826663/ /pubmed/31590423 http://dx.doi.org/10.3390/antiox8100454 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kuznetsov, Andrey V.
Javadov, Sabzali
Margreiter, Raimund
Grimm, Michael
Hagenbuchner, Judith
Ausserlechner, Michael J.
The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury
title The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury
title_full The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury
title_fullStr The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury
title_full_unstemmed The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury
title_short The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury
title_sort role of mitochondria in the mechanisms of cardiac ischemia-reperfusion injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826663/
https://www.ncbi.nlm.nih.gov/pubmed/31590423
http://dx.doi.org/10.3390/antiox8100454
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