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Evaluation of Intensity- and Contour-Based Deformable Image Registration Accuracy in Pancreatic Cancer Patients

We aimed to clarify the accuracy of rigid image registration and deformable image registration (DIR) in carbon-ion radiotherapy (CIRT) for pancreatic cancer. Six patients with pancreatic cancer who were treated with passive irradiation CIRT were enrolled. Three registration patterns were evaluated:...

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Autores principales: Kubota, Yoshiki, Okamoto, Masahiko, Li, Yang, Shiba, Shintaro, Okazaki, Shohei, Komatsu, Shuichiro, Sakai, Makoto, Kubo, Nobuteru, Ohno, Tatsuya, Nakano, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826682/
https://www.ncbi.nlm.nih.gov/pubmed/31569617
http://dx.doi.org/10.3390/cancers11101447
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author Kubota, Yoshiki
Okamoto, Masahiko
Li, Yang
Shiba, Shintaro
Okazaki, Shohei
Komatsu, Shuichiro
Sakai, Makoto
Kubo, Nobuteru
Ohno, Tatsuya
Nakano, Takashi
author_facet Kubota, Yoshiki
Okamoto, Masahiko
Li, Yang
Shiba, Shintaro
Okazaki, Shohei
Komatsu, Shuichiro
Sakai, Makoto
Kubo, Nobuteru
Ohno, Tatsuya
Nakano, Takashi
author_sort Kubota, Yoshiki
collection PubMed
description We aimed to clarify the accuracy of rigid image registration and deformable image registration (DIR) in carbon-ion radiotherapy (CIRT) for pancreatic cancer. Six patients with pancreatic cancer who were treated with passive irradiation CIRT were enrolled. Three registration patterns were evaluated: treatment planning computed tomography images (TPCT) to CT images acquired in the treatment room (IRCT) in the supine position, TPCT to IRCT in the prone position, and TPCT in the supine position to the prone position. After warping the contours of the original CT images to the destination CT images using deformation matrices from the registration, the warped delineated contours on the destination CT images were compared with the original ones using mean displacement to agreement (MDA). Four contours (clinical target volume (CTV), gross tumor volume (GTV), stomach, duodenum) and four registration algorithms (rigid image registration [RIR], intensity-based DIR [iDIR], contour-based DIR [cDIR], and a hybrid iDIR-cDIR ([hDIR]) were evaluated. The means ± standard deviation of the MDAs of all contours for RIR, iDIR, cDIR, and hDIR were 3.40 ± 3.30, 2.2 1± 2.48, 1.46 ± 1.49, and 1.46 ± 1.37 mm, respectively. There were significant differences between RIR and iDIR, and between RIR/iDIR and cDIR/hDIR. For the pancreatic cancer patient images, cDIR and hDIR had better accuracy than RIR and iDIR.
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spelling pubmed-68266822019-11-18 Evaluation of Intensity- and Contour-Based Deformable Image Registration Accuracy in Pancreatic Cancer Patients Kubota, Yoshiki Okamoto, Masahiko Li, Yang Shiba, Shintaro Okazaki, Shohei Komatsu, Shuichiro Sakai, Makoto Kubo, Nobuteru Ohno, Tatsuya Nakano, Takashi Cancers (Basel) Article We aimed to clarify the accuracy of rigid image registration and deformable image registration (DIR) in carbon-ion radiotherapy (CIRT) for pancreatic cancer. Six patients with pancreatic cancer who were treated with passive irradiation CIRT were enrolled. Three registration patterns were evaluated: treatment planning computed tomography images (TPCT) to CT images acquired in the treatment room (IRCT) in the supine position, TPCT to IRCT in the prone position, and TPCT in the supine position to the prone position. After warping the contours of the original CT images to the destination CT images using deformation matrices from the registration, the warped delineated contours on the destination CT images were compared with the original ones using mean displacement to agreement (MDA). Four contours (clinical target volume (CTV), gross tumor volume (GTV), stomach, duodenum) and four registration algorithms (rigid image registration [RIR], intensity-based DIR [iDIR], contour-based DIR [cDIR], and a hybrid iDIR-cDIR ([hDIR]) were evaluated. The means ± standard deviation of the MDAs of all contours for RIR, iDIR, cDIR, and hDIR were 3.40 ± 3.30, 2.2 1± 2.48, 1.46 ± 1.49, and 1.46 ± 1.37 mm, respectively. There were significant differences between RIR and iDIR, and between RIR/iDIR and cDIR/hDIR. For the pancreatic cancer patient images, cDIR and hDIR had better accuracy than RIR and iDIR. MDPI 2019-09-27 /pmc/articles/PMC6826682/ /pubmed/31569617 http://dx.doi.org/10.3390/cancers11101447 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kubota, Yoshiki
Okamoto, Masahiko
Li, Yang
Shiba, Shintaro
Okazaki, Shohei
Komatsu, Shuichiro
Sakai, Makoto
Kubo, Nobuteru
Ohno, Tatsuya
Nakano, Takashi
Evaluation of Intensity- and Contour-Based Deformable Image Registration Accuracy in Pancreatic Cancer Patients
title Evaluation of Intensity- and Contour-Based Deformable Image Registration Accuracy in Pancreatic Cancer Patients
title_full Evaluation of Intensity- and Contour-Based Deformable Image Registration Accuracy in Pancreatic Cancer Patients
title_fullStr Evaluation of Intensity- and Contour-Based Deformable Image Registration Accuracy in Pancreatic Cancer Patients
title_full_unstemmed Evaluation of Intensity- and Contour-Based Deformable Image Registration Accuracy in Pancreatic Cancer Patients
title_short Evaluation of Intensity- and Contour-Based Deformable Image Registration Accuracy in Pancreatic Cancer Patients
title_sort evaluation of intensity- and contour-based deformable image registration accuracy in pancreatic cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826682/
https://www.ncbi.nlm.nih.gov/pubmed/31569617
http://dx.doi.org/10.3390/cancers11101447
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