Cargando…
Protective Effect of Selected Antioxidants on Naproxen Photodegradation in Aqueous Media
A photostabilization strategy is an important aspect of quality assurance for photosensitive compounds. This study focused on the photoprotective effects of selected antioxidants including the effect of L-ascorbic acid (AA) on naproxen (NX) photodegradation in aqueous media. NX degradation during ul...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826686/ https://www.ncbi.nlm.nih.gov/pubmed/31547495 http://dx.doi.org/10.3390/antiox8100424 |
_version_ | 1783465149475061760 |
---|---|
author | Kawabata, Kohei Takato, Ayaka Oshima, Sayaka Akimoto, Shiori Inagaki, Masanori Nishi, Hiroyuki |
author_facet | Kawabata, Kohei Takato, Ayaka Oshima, Sayaka Akimoto, Shiori Inagaki, Masanori Nishi, Hiroyuki |
author_sort | Kawabata, Kohei |
collection | PubMed |
description | A photostabilization strategy is an important aspect of quality assurance for photosensitive compounds. This study focused on the photoprotective effects of selected antioxidants including the effect of L-ascorbic acid (AA) on naproxen (NX) photodegradation in aqueous media. NX degradation during ultraviolet light (UV) irradiation and the protective effects of selected antioxidants were monitored by high-performance liquid chromatography (HPLC). The addition of AA induced the suppression of NX photodegradation, although the protective effect disappeared after AA was degraded completely. The results of the evaluations on the photoprotective effects on NX photodegradation and antioxidative activities of AA and other antioxidants showed that the protective effects of antioxidants are dependent on reducing power and photostability under UV irradiation. In this experiment, quercetin (QU) is the most effective antioxidant on account of the residual rate of QU after UV irradiation and the antioxidative activity in the potential antioxidant (PAO) test was significantly higher compared to other antioxidants following the higher protective effect on NX photodegradation. |
format | Online Article Text |
id | pubmed-6826686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68266862019-11-18 Protective Effect of Selected Antioxidants on Naproxen Photodegradation in Aqueous Media Kawabata, Kohei Takato, Ayaka Oshima, Sayaka Akimoto, Shiori Inagaki, Masanori Nishi, Hiroyuki Antioxidants (Basel) Article A photostabilization strategy is an important aspect of quality assurance for photosensitive compounds. This study focused on the photoprotective effects of selected antioxidants including the effect of L-ascorbic acid (AA) on naproxen (NX) photodegradation in aqueous media. NX degradation during ultraviolet light (UV) irradiation and the protective effects of selected antioxidants were monitored by high-performance liquid chromatography (HPLC). The addition of AA induced the suppression of NX photodegradation, although the protective effect disappeared after AA was degraded completely. The results of the evaluations on the photoprotective effects on NX photodegradation and antioxidative activities of AA and other antioxidants showed that the protective effects of antioxidants are dependent on reducing power and photostability under UV irradiation. In this experiment, quercetin (QU) is the most effective antioxidant on account of the residual rate of QU after UV irradiation and the antioxidative activity in the potential antioxidant (PAO) test was significantly higher compared to other antioxidants following the higher protective effect on NX photodegradation. MDPI 2019-09-23 /pmc/articles/PMC6826686/ /pubmed/31547495 http://dx.doi.org/10.3390/antiox8100424 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kawabata, Kohei Takato, Ayaka Oshima, Sayaka Akimoto, Shiori Inagaki, Masanori Nishi, Hiroyuki Protective Effect of Selected Antioxidants on Naproxen Photodegradation in Aqueous Media |
title | Protective Effect of Selected Antioxidants on Naproxen Photodegradation in Aqueous Media |
title_full | Protective Effect of Selected Antioxidants on Naproxen Photodegradation in Aqueous Media |
title_fullStr | Protective Effect of Selected Antioxidants on Naproxen Photodegradation in Aqueous Media |
title_full_unstemmed | Protective Effect of Selected Antioxidants on Naproxen Photodegradation in Aqueous Media |
title_short | Protective Effect of Selected Antioxidants on Naproxen Photodegradation in Aqueous Media |
title_sort | protective effect of selected antioxidants on naproxen photodegradation in aqueous media |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826686/ https://www.ncbi.nlm.nih.gov/pubmed/31547495 http://dx.doi.org/10.3390/antiox8100424 |
work_keys_str_mv | AT kawabatakohei protectiveeffectofselectedantioxidantsonnaproxenphotodegradationinaqueousmedia AT takatoayaka protectiveeffectofselectedantioxidantsonnaproxenphotodegradationinaqueousmedia AT oshimasayaka protectiveeffectofselectedantioxidantsonnaproxenphotodegradationinaqueousmedia AT akimotoshiori protectiveeffectofselectedantioxidantsonnaproxenphotodegradationinaqueousmedia AT inagakimasanori protectiveeffectofselectedantioxidantsonnaproxenphotodegradationinaqueousmedia AT nishihiroyuki protectiveeffectofselectedantioxidantsonnaproxenphotodegradationinaqueousmedia |