The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease

Melatonin is a hormone that is secreted by the pineal gland. To date, melatonin is known to regulate the sleep cycle by controlling the circadian rhythm. However, recent advances in neuroscience and molecular biology have led to the discovery of new actions and effects of melatonin. In recent studie...

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Autores principales: Lee, Jung Goo, Woo, Young Sup, Park, Sung Woo, Seog, Dae-Hyun, Seo, Mi Kyoung, Bahk, Won-Myong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826722/
https://www.ncbi.nlm.nih.gov/pubmed/31640239
http://dx.doi.org/10.3390/brainsci9100285
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author Lee, Jung Goo
Woo, Young Sup
Park, Sung Woo
Seog, Dae-Hyun
Seo, Mi Kyoung
Bahk, Won-Myong
author_facet Lee, Jung Goo
Woo, Young Sup
Park, Sung Woo
Seog, Dae-Hyun
Seo, Mi Kyoung
Bahk, Won-Myong
author_sort Lee, Jung Goo
collection PubMed
description Melatonin is a hormone that is secreted by the pineal gland. To date, melatonin is known to regulate the sleep cycle by controlling the circadian rhythm. However, recent advances in neuroscience and molecular biology have led to the discovery of new actions and effects of melatonin. In recent studies, melatonin was shown to have antioxidant activity and, possibly, to affect the development of Alzheimer’s disease (AD). In addition, melatonin has neuroprotective effects and affects neuroplasticity, thus indicating potential antidepressant properties. In the present review, the new functions of melatonin are summarized and a therapeutic target for the development of new drugs based on the mechanism of action of melatonin is proposed.
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spelling pubmed-68267222019-11-18 The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease Lee, Jung Goo Woo, Young Sup Park, Sung Woo Seog, Dae-Hyun Seo, Mi Kyoung Bahk, Won-Myong Brain Sci Perspective Melatonin is a hormone that is secreted by the pineal gland. To date, melatonin is known to regulate the sleep cycle by controlling the circadian rhythm. However, recent advances in neuroscience and molecular biology have led to the discovery of new actions and effects of melatonin. In recent studies, melatonin was shown to have antioxidant activity and, possibly, to affect the development of Alzheimer’s disease (AD). In addition, melatonin has neuroprotective effects and affects neuroplasticity, thus indicating potential antidepressant properties. In the present review, the new functions of melatonin are summarized and a therapeutic target for the development of new drugs based on the mechanism of action of melatonin is proposed. MDPI 2019-10-21 /pmc/articles/PMC6826722/ /pubmed/31640239 http://dx.doi.org/10.3390/brainsci9100285 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Lee, Jung Goo
Woo, Young Sup
Park, Sung Woo
Seog, Dae-Hyun
Seo, Mi Kyoung
Bahk, Won-Myong
The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease
title The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease
title_full The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease
title_fullStr The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease
title_full_unstemmed The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease
title_short The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease
title_sort neuroprotective effects of melatonin: possible role in the pathophysiology of neuropsychiatric disease
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826722/
https://www.ncbi.nlm.nih.gov/pubmed/31640239
http://dx.doi.org/10.3390/brainsci9100285
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