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Epigenetic Reprogramming for Targeting IDH-Mutant Malignant Gliomas
Targeting the epigenome has been considered a compelling treatment modality for several cancers, including gliomas. Nearly 80% of the lower-grade gliomas and secondary glioblastomas harbor recurrent mutations in isocitrate dehydrogenase (IDH). Mutant IDH generates high levels of 2-hydroxyglutarate (...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826741/ https://www.ncbi.nlm.nih.gov/pubmed/31652645 http://dx.doi.org/10.3390/cancers11101616 |