Cargando…

Quantification of [(18)F]florbetapir: A test–retest tracer kinetic modelling study

Accumulation of amyloid beta can be visualized using [(18)F]florbetapir positron emission tomography. The aim of this study was to identify the optimal model for quantifying [(18)F]florbetapir uptake and to assess test–retest reliability of corresponding outcome measures. Eight Alzheimer’s disease p...

Descripción completa

Detalles Bibliográficos
Autores principales: Golla, Sandeep SV, Verfaillie, Sander CJ, Boellaard, Ronald, Adriaanse, Sofie M, Zwan, Marissa D, Schuit, Robert C, Timmers, Tessa, Groot, Colin, Schober, Patrick, Scheltens, Philip, van der Flier, Wiesje M, Windhorst, Albert D, van Berckel, Bart NM, Lammertsma, Adriaan A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826855/
https://www.ncbi.nlm.nih.gov/pubmed/29897009
http://dx.doi.org/10.1177/0271678X18783628
_version_ 1783465190090604544
author Golla, Sandeep SV
Verfaillie, Sander CJ
Boellaard, Ronald
Adriaanse, Sofie M
Zwan, Marissa D
Schuit, Robert C
Timmers, Tessa
Groot, Colin
Schober, Patrick
Scheltens, Philip
van der Flier, Wiesje M
Windhorst, Albert D
van Berckel, Bart NM
Lammertsma, Adriaan A
author_facet Golla, Sandeep SV
Verfaillie, Sander CJ
Boellaard, Ronald
Adriaanse, Sofie M
Zwan, Marissa D
Schuit, Robert C
Timmers, Tessa
Groot, Colin
Schober, Patrick
Scheltens, Philip
van der Flier, Wiesje M
Windhorst, Albert D
van Berckel, Bart NM
Lammertsma, Adriaan A
author_sort Golla, Sandeep SV
collection PubMed
description Accumulation of amyloid beta can be visualized using [(18)F]florbetapir positron emission tomography. The aim of this study was to identify the optimal model for quantifying [(18)F]florbetapir uptake and to assess test–retest reliability of corresponding outcome measures. Eight Alzheimer’s disease patients (age: 67 ± 6 years, Mini-Mental State Examination (MMSE): 23 ± 3) and eight controls (age: 63 ± 4 years, MMSE: 30 ± 0) were included. Ninety-minute dynamic positron emission tomography scans, together with arterial blood sampling, were acquired immediately following a bolus injection of 294 ± 32 MBq [(18)F]florbetapir. Several plasma input models and the simplified reference tissue model (SRTM) were evaluated. The Akaike information criterion was used to identify the preferred kinetic model. Compared to controls, Alzheimer’s disease patients had lower MMSE scores and evidence for cortical Aβ pathology. A reversible two-tissue compartment model with fitted blood volume fraction (2T4k_V(B)) was the preferred model for describing [(18)F]florbetapir kinetics. SRTM-derived non-displaceable binding potential (BP(ND)) correlated well (r(2 )= 0.83, slope = 0.86) with plasma input-derived distribution volume ratio. Test–retest reliability for plasma input-derived distribution volume ratio, SRTM-derived BP(ND) and SUVr((50–70)) were r = 0.88, r = 0.91 and r = 0.86, respectively. In vivo kinetics of [(18)F]florbetapir could best be described by a reversible two-tissue compartmental model and [(18)F]florbetapir BP(ND) can be reliably estimated using an SRTM.
format Online
Article
Text
id pubmed-6826855
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-68268552019-12-04 Quantification of [(18)F]florbetapir: A test–retest tracer kinetic modelling study Golla, Sandeep SV Verfaillie, Sander CJ Boellaard, Ronald Adriaanse, Sofie M Zwan, Marissa D Schuit, Robert C Timmers, Tessa Groot, Colin Schober, Patrick Scheltens, Philip van der Flier, Wiesje M Windhorst, Albert D van Berckel, Bart NM Lammertsma, Adriaan A J Cereb Blood Flow Metab Original Articles Accumulation of amyloid beta can be visualized using [(18)F]florbetapir positron emission tomography. The aim of this study was to identify the optimal model for quantifying [(18)F]florbetapir uptake and to assess test–retest reliability of corresponding outcome measures. Eight Alzheimer’s disease patients (age: 67 ± 6 years, Mini-Mental State Examination (MMSE): 23 ± 3) and eight controls (age: 63 ± 4 years, MMSE: 30 ± 0) were included. Ninety-minute dynamic positron emission tomography scans, together with arterial blood sampling, were acquired immediately following a bolus injection of 294 ± 32 MBq [(18)F]florbetapir. Several plasma input models and the simplified reference tissue model (SRTM) were evaluated. The Akaike information criterion was used to identify the preferred kinetic model. Compared to controls, Alzheimer’s disease patients had lower MMSE scores and evidence for cortical Aβ pathology. A reversible two-tissue compartment model with fitted blood volume fraction (2T4k_V(B)) was the preferred model for describing [(18)F]florbetapir kinetics. SRTM-derived non-displaceable binding potential (BP(ND)) correlated well (r(2 )= 0.83, slope = 0.86) with plasma input-derived distribution volume ratio. Test–retest reliability for plasma input-derived distribution volume ratio, SRTM-derived BP(ND) and SUVr((50–70)) were r = 0.88, r = 0.91 and r = 0.86, respectively. In vivo kinetics of [(18)F]florbetapir could best be described by a reversible two-tissue compartmental model and [(18)F]florbetapir BP(ND) can be reliably estimated using an SRTM. SAGE Publications 2018-06-13 2019-11 /pmc/articles/PMC6826855/ /pubmed/29897009 http://dx.doi.org/10.1177/0271678X18783628 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Golla, Sandeep SV
Verfaillie, Sander CJ
Boellaard, Ronald
Adriaanse, Sofie M
Zwan, Marissa D
Schuit, Robert C
Timmers, Tessa
Groot, Colin
Schober, Patrick
Scheltens, Philip
van der Flier, Wiesje M
Windhorst, Albert D
van Berckel, Bart NM
Lammertsma, Adriaan A
Quantification of [(18)F]florbetapir: A test–retest tracer kinetic modelling study
title Quantification of [(18)F]florbetapir: A test–retest tracer kinetic modelling study
title_full Quantification of [(18)F]florbetapir: A test–retest tracer kinetic modelling study
title_fullStr Quantification of [(18)F]florbetapir: A test–retest tracer kinetic modelling study
title_full_unstemmed Quantification of [(18)F]florbetapir: A test–retest tracer kinetic modelling study
title_short Quantification of [(18)F]florbetapir: A test–retest tracer kinetic modelling study
title_sort quantification of [(18)f]florbetapir: a test–retest tracer kinetic modelling study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826855/
https://www.ncbi.nlm.nih.gov/pubmed/29897009
http://dx.doi.org/10.1177/0271678X18783628
work_keys_str_mv AT gollasandeepsv quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy
AT verfailliesandercj quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy
AT boellaardronald quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy
AT adriaansesofiem quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy
AT zwanmarissad quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy
AT schuitrobertc quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy
AT timmerstessa quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy
AT grootcolin quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy
AT schoberpatrick quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy
AT scheltensphilip quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy
AT vanderflierwiesjem quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy
AT windhorstalbertd quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy
AT vanberckelbartnm quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy
AT lammertsmaadriaana quantificationof18fflorbetapiratestretesttracerkineticmodellingstudy