The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses

Expression of TRAIL (tumor necrosis factor–related apoptosis–inducing ligand) by immune cells can lead to the induction of apoptosis in tumor cells. However, it becomes increasingly clear that the interaction of TRAIL and its death receptors (DRs) can also directly impact immune cells and influence...

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Detalles Bibliográficos
Autores principales: Sag, Duygu, Ayyildiz, Zeynep Ozge, Gunalp, Sinem, Wingender, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826877/
https://www.ncbi.nlm.nih.gov/pubmed/31574961
http://dx.doi.org/10.3390/cancers11101469
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author Sag, Duygu
Ayyildiz, Zeynep Ozge
Gunalp, Sinem
Wingender, Gerhard
author_facet Sag, Duygu
Ayyildiz, Zeynep Ozge
Gunalp, Sinem
Wingender, Gerhard
author_sort Sag, Duygu
collection PubMed
description Expression of TRAIL (tumor necrosis factor–related apoptosis–inducing ligand) by immune cells can lead to the induction of apoptosis in tumor cells. However, it becomes increasingly clear that the interaction of TRAIL and its death receptors (DRs) can also directly impact immune cells and influence immune responses. Here, we review what is known about the role of TRAIL/DRs in immune cells and immune responses in general and in the tumor microenvironment in particular.
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spelling pubmed-68268772019-11-18 The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses Sag, Duygu Ayyildiz, Zeynep Ozge Gunalp, Sinem Wingender, Gerhard Cancers (Basel) Review Expression of TRAIL (tumor necrosis factor–related apoptosis–inducing ligand) by immune cells can lead to the induction of apoptosis in tumor cells. However, it becomes increasingly clear that the interaction of TRAIL and its death receptors (DRs) can also directly impact immune cells and influence immune responses. Here, we review what is known about the role of TRAIL/DRs in immune cells and immune responses in general and in the tumor microenvironment in particular. MDPI 2019-09-30 /pmc/articles/PMC6826877/ /pubmed/31574961 http://dx.doi.org/10.3390/cancers11101469 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sag, Duygu
Ayyildiz, Zeynep Ozge
Gunalp, Sinem
Wingender, Gerhard
The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses
title The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses
title_full The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses
title_fullStr The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses
title_full_unstemmed The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses
title_short The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses
title_sort role of trail/drs in the modulation of immune cells and responses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826877/
https://www.ncbi.nlm.nih.gov/pubmed/31574961
http://dx.doi.org/10.3390/cancers11101469
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