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Transcriptional Networks of Microglia in Alzheimer’s Disease and Insights into Pathogenesis
Microglia, the main immune cells of the central nervous system, are increasingly implicated in Alzheimer’s disease (AD). Manifold transcriptomic studies in the brain have not only highlighted microglia’s role in AD pathogenesis, but also mapped crucial pathological processes and identified new thera...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826883/ https://www.ncbi.nlm.nih.gov/pubmed/31614849 http://dx.doi.org/10.3390/genes10100798 |
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author | Chew, Gabriel Petretto, Enrico |
author_facet | Chew, Gabriel Petretto, Enrico |
author_sort | Chew, Gabriel |
collection | PubMed |
description | Microglia, the main immune cells of the central nervous system, are increasingly implicated in Alzheimer’s disease (AD). Manifold transcriptomic studies in the brain have not only highlighted microglia’s role in AD pathogenesis, but also mapped crucial pathological processes and identified new therapeutic targets. An important component of many of these transcriptomic studies is the investigation of gene expression networks in AD brain, which has provided important new insights into how coordinated gene regulatory programs in microglia (and other cell types) underlie AD pathogenesis. Given the rapid technological advancements in transcriptional profiling, spanning from microarrays to single-cell RNA sequencing (scRNA-seq), tools used for mapping gene expression networks have evolved to keep pace with the unique features of each transcriptomic platform. In this article, we review the trajectory of transcriptomic network analyses in AD from brain to microglia, highlighting the corresponding methodological developments. Lastly, we discuss examples of how transcriptional network analysis provides new insights into AD mechanisms and pathogenesis. |
format | Online Article Text |
id | pubmed-6826883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68268832019-11-18 Transcriptional Networks of Microglia in Alzheimer’s Disease and Insights into Pathogenesis Chew, Gabriel Petretto, Enrico Genes (Basel) Review Microglia, the main immune cells of the central nervous system, are increasingly implicated in Alzheimer’s disease (AD). Manifold transcriptomic studies in the brain have not only highlighted microglia’s role in AD pathogenesis, but also mapped crucial pathological processes and identified new therapeutic targets. An important component of many of these transcriptomic studies is the investigation of gene expression networks in AD brain, which has provided important new insights into how coordinated gene regulatory programs in microglia (and other cell types) underlie AD pathogenesis. Given the rapid technological advancements in transcriptional profiling, spanning from microarrays to single-cell RNA sequencing (scRNA-seq), tools used for mapping gene expression networks have evolved to keep pace with the unique features of each transcriptomic platform. In this article, we review the trajectory of transcriptomic network analyses in AD from brain to microglia, highlighting the corresponding methodological developments. Lastly, we discuss examples of how transcriptional network analysis provides new insights into AD mechanisms and pathogenesis. MDPI 2019-10-12 /pmc/articles/PMC6826883/ /pubmed/31614849 http://dx.doi.org/10.3390/genes10100798 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chew, Gabriel Petretto, Enrico Transcriptional Networks of Microglia in Alzheimer’s Disease and Insights into Pathogenesis |
title | Transcriptional Networks of Microglia in Alzheimer’s Disease and Insights into Pathogenesis |
title_full | Transcriptional Networks of Microglia in Alzheimer’s Disease and Insights into Pathogenesis |
title_fullStr | Transcriptional Networks of Microglia in Alzheimer’s Disease and Insights into Pathogenesis |
title_full_unstemmed | Transcriptional Networks of Microglia in Alzheimer’s Disease and Insights into Pathogenesis |
title_short | Transcriptional Networks of Microglia in Alzheimer’s Disease and Insights into Pathogenesis |
title_sort | transcriptional networks of microglia in alzheimer’s disease and insights into pathogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826883/ https://www.ncbi.nlm.nih.gov/pubmed/31614849 http://dx.doi.org/10.3390/genes10100798 |
work_keys_str_mv | AT chewgabriel transcriptionalnetworksofmicrogliainalzheimersdiseaseandinsightsintopathogenesis AT petrettoenrico transcriptionalnetworksofmicrogliainalzheimersdiseaseandinsightsintopathogenesis |