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The Novel Phosphatidylinositol-3-Kinase (PI3K) Inhibitor Alpelisib Effectively Inhibits Growth of PTEN-Haploinsufficient Lipoma Cells

Germline mutations in the tumor suppressor gene PTEN cause PTEN Hamartoma Tumor Syndrome (PHTS). Pediatric patients with PHTS frequently develop lipomas. Treatment attempts with the mTORC1 inhibitor rapamycin were unable to reverse lipoma growth. Recently, lipomas associated with PIK3CA-related over...

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Detalles Bibliográficos
Autores principales:	Kirstein, Anna S., Augustin, Adrien, Penke, Melanie, Cea, Michele, Körner, Antje, Kiess, Wieland, Garten, Antje
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826943/ https://www.ncbi.nlm.nih.gov/pubmed/31627436 http://dx.doi.org/10.3390/cancers11101586

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