Mutational Landscape of the BAP1 Locus Reveals an Intrinsic Control to Regulate the miRNA Network and the Binding of Protein Complexes in Uveal Melanoma

The BAP1 (BRCA1-associated protein 1) gene is associated with a variety of human cancers. With its gene product being a nuclear ubiquitin carboxy-terminal hydrolase with deubiquitinase activity, BAP1 acts as a tumor suppressor gene with potential pleiotropic effects in multiple tumor types. Herein,...

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Detalles Bibliográficos
Autores principales: Sharma, Amit, Biswas, Arijit, Liu, Hongde, Sen, Sagnik, Paruchuri, Anoosha, Katsonis, Panagiotis, Lichtarge, Olivier, Chand Dakal, Tikam, Maulik, Ujjwal, Gromiha, M. Michael, Bandyopadhyay, Sanghamitra, Ludwig, Michael, Holz, Frank G., Loeffler, Karin U., Herwig-Carl, Martina C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826957/
https://www.ncbi.nlm.nih.gov/pubmed/31635116
http://dx.doi.org/10.3390/cancers11101600

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