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A Humanized Yeast Phenomic Model of Deoxycytidine Kinase to Predict Genetic Buffering of Nucleoside Analog Cytotoxicity

Knowledge about synthetic lethality can be applied to enhance the efficacy of anticancer therapies in individual patients harboring genetic alterations in their cancer that specifically render it vulnerable. We investigated the potential for high-resolution phenomic analysis in yeast to predict such...

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Detalles Bibliográficos
Autores principales:	Santos, Sean M., Icyuz, Mert, Pound, Ilya, William, Doreen, Guo, Jingyu, McKinney, Brett A., Niederweis, Michael, Rodgers, John, Hartman, John L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826991/ https://www.ncbi.nlm.nih.gov/pubmed/31575041 http://dx.doi.org/10.3390/genes10100770

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