Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats

Acute kidney injury (AKI) is a serious complication of methotrexate (MTX). This study explored the protective effect of the isoflavone formononetin (FN) against MTX nephrotoxicity with an emphasis on oxidative stress, inflammation, and nuclear factor (erythroid-derived 2)-like 2/heme oxygenase 1 (Nr...

Descripción completa

Detalles Bibliográficos
Autores principales: Aladaileh, Saleem H., Hussein, Omnia E., Abukhalil, Mohammad H., Saghir, Sultan A. M., Bin-Jumah, May, Alfwuaires, Manal A., Germoush, Mousa O., Almaiman, Amer A., Mahmoud, Ayman M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827027/
https://www.ncbi.nlm.nih.gov/pubmed/31561418
http://dx.doi.org/10.3390/antiox8100430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827027/
https://www.ncbi.nlm.nih.gov/pubmed/31561418
http://dx.doi.org/10.3390/antiox8100430

Ejemplares similares