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Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats

Acute kidney injury (AKI) is a serious complication of methotrexate (MTX). This study explored the protective effect of the isoflavone formononetin (FN) against MTX nephrotoxicity with an emphasis on oxidative stress, inflammation, and nuclear factor (erythroid-derived 2)-like 2/heme oxygenase 1 (Nr...

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Detalles Bibliográficos
Autores principales:	Aladaileh, Saleem H., Hussein, Omnia E., Abukhalil, Mohammad H., Saghir, Sultan A. M., Bin-Jumah, May, Alfwuaires, Manal A., Germoush, Mousa O., Almaiman, Amer A., Mahmoud, Ayman M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827027/ https://www.ncbi.nlm.nih.gov/pubmed/31561418 http://dx.doi.org/10.3390/antiox8100430

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