Landscape of Germline Mutations in DNA Repair Genes for Breast Cancer in Latin America: Opportunities for PARP-Like Inhibitors and Immunotherapy

Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes are present in about 50% of cases of hereditary breast cancer. Proteins encoded by these genes are key players in DNA repair by homologous recombination (HR). Advances in next generation sequencing and gene panels for breast cancer testing have g...

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Detalles Bibliográficos
Autores principales: Urbina-Jara, Laura Keren, Rojas-Martinez, Augusto, Martinez-Ledesma, Emmanuel, Aguilar, Dione, Villarreal-Garza, Cynthia, Ortiz-Lopez, Rocio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827033/
https://www.ncbi.nlm.nih.gov/pubmed/31658756
http://dx.doi.org/10.3390/genes10100786

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