Cargando…

STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer

Signal transducer and activator of transcription 3 (STAT3) is an oncogene and multifaceted transcription factor involved in multiple cellular functions. Its role in modifying anti-tumor immunity has been recently recognized. In this study, the biologic effects of STAT3 on immune checkpoint expressio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zerdes, Ioannis, Wallerius, Majken, Sifakis, Emmanouil G., Wallmann, Tatjana, Betts, Stina, Bartish, Margarita, Tsesmetzis, Nikolaos, Tobin, Nicholas P., Coucoravas, Christos, Bergh, Jonas, Rassidakis, George Z., Rolny, Charlotte, Foukakis, Theodoros
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827034/ https://www.ncbi.nlm.nih.gov/pubmed/31581535 http://dx.doi.org/10.3390/cancers11101479

Ejemplares similares

Programmed death‐ligand 1 gene expression is a prognostic marker in early breast cancer and provides additional prognostic value to 21‐gene and 70‐gene signatures in estrogen receptor‐positive disease
por: Zerdes, Ioannis, et al.
Publicado: (2020)

PD-1 protein and gene expression as prognostic factors in early breast cancer
por: Matikas, Alexios, et al.
Publicado: (2020)

Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations
por: Zerdes, Ioannis, et al.
Publicado: (2018)

Beyond PD-1/PD-L1 Inhibition: What the Future Holds for Breast Cancer Immunotherapy
por: Chrétien, Sebastian, et al.
Publicado: (2019)

Discordance of PD-L1 Expression at the Protein and RNA Levels in Early Breast Cancer
por: Zerdes, Ioannis, et al.
Publicado: (2021)

The interplay between eosinophils and T cells in breast cancer immunotherapy
por: Zerdes, Ioannis, et al.
Publicado: (2023)

Expression patterns and prognostic implications of tumor-infiltrating lymphocytes dynamics in early breast cancer patients receiving neoadjuvant therapy: A systematic review and meta-analysis
por: Zhu, Yajing, et al.
Publicado: (2022)

Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity
por: Wallmann, Tatjana, et al.
Publicado: (2018)

Dissecting Tumor-Immune Microenvironment in Breast Cancer at a Spatial and Multiplex Resolution
por: Tzoras, Evangelos, et al.
Publicado: (2022)

The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours
por: Lundberg, Arian, et al.
Publicado: (2019)

Immune gene expression and response to chemotherapy in advanced breast cancer
por: Foukakis, Theodoros, et al.
Publicado: (2018)

Clinical instability of breast cancer markers is reflected in long-term in vitro estrogen deprivation studies
por: Milosevic, Jelena, et al.
Publicado: (2013)

Interplay between copy number alterations and immune profiles in the early breast cancer Scandinavian Breast Group 2004-1 randomized phase II trial: results from a feasibility study
por: Zerdes, Ioannis, et al.
Publicado: (2021)

Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction
por: Chen, Xinsong, et al.
Publicado: (2022)

Women with short survival after diagnosis of metastatic breast cancer: a population-based registry study
por: Boman, Caroline, et al.
Publicado: (2022)

The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1
por: Rassoolzadeh, Hanif, et al.
Publicado: (2016)

Avoiding over- and undertreatment in patients with resected node-positive breast cancer with the use of gene expression signatures: are we there yet?
por: Matikas, A, et al.
Publicado: (2019)

ALK+ Anaplastic Large Cell Lymphoma (ALCL)-Derived Exosomes Carry ALK Signaling Proteins and Interact with Tumor Microenvironment
por: Chioureas, Dimitrios, et al.
Publicado: (2022)

Validation of a novel procedure for quantification of the formation of phosphoramide mustard by individuals treated with cyclophosphamide
por: von Stedingk, Hans, et al.
Publicado: (2014)

Chemotherapy use near the end-of-life in patients with metastatic breast cancer
por: Edman Kessler, Luisa, et al.
Publicado: (2020)

Verrucous Carcinoma of the Vulva: A Case Report
por: Boutas, Ioannis, et al.
Publicado: (2013)

Soft Sensing of LPG Processes Using Deep Learning
por: Sifakis, Nikolaos, et al.
Publicado: (2023)

Long-term (up to 16 months) health-related quality of life after adjuvant tailored dose-dense chemotherapy vs. standard three-weekly chemotherapy in women with high-risk early breast cancer
por: Brandberg, Yvonne, et al.
Publicado: (2020)

Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response
por: Coucoravas, Christos, et al.
Publicado: (2016)

Treatment Options for Abdominal Rectus Diastasis
por: Jessen, Majken Lyhne, et al.
Publicado: (2019)

Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy
por: Bartish, Margarita, et al.
Publicado: (2020)

Discordance of PIK3CA mutational status between primary and metastatic breast cancer: a systematic review and meta-analysis
por: Rosin, Justus, et al.
Publicado: (2023)

Prognostic role of serum thymidine kinase 1 kinetics during neoadjuvant chemotherapy for early breast cancer
por: Matikas, A., et al.
Publicado: (2021)

Potential role of AKT/mTOR signalling proteins in hairy cell leukaemia: association with BRAF/ERK activation and clinical outcome
por: Lakiotaki, Eleftheria, et al.
Publicado: (2016)

Improving tissue characterization, differentiation and diagnosis in gynecology with the narrow-band imaging technique: A systematic review
por: Peitsidis, Panagiotis, et al.
Publicado: (2022)

Future mobile communication: from cooperative cells to the post-cellular relay carpet
por: Rolny, Raphael T L
Publicado: (2016)

Prenatal diagnosis of Wolf-Hirschhorn syndrome confirmed by comparative genomic hybridization array: report of two cases and review of the literature
por: Sifakis, Stavros, et al.
Publicado: (2012)

Climatic Changes and Orogeneses in the Late Miocene of Eurasia: The Main Triggers of an Expansion at a Continental Scale?
por: Jia, Dong-Rui, et al.
Publicado: (2018)

Asymmetric competition over space use and territory between native brown trout (Salmo trutta) and invasive brook trout (Salvelinus fontinalis)
por: Lovén Wallerius, Magnus, et al.
Publicado: (2022)

Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism
por: Tsesmetzis, Nikolaos, et al.
Publicado: (2018)

Anthropogenic threats to evolutionary heritage of angiosperms in the Netherlands through an increase in high‐competition environments
por: Bartish, Igor V., et al.
Publicado: (2020)

Dynamic evaluation of the immune infiltrate and immune function genes as predictive markers for neoadjuvant chemotherapy in hormone receptor positive, HER2 negative breast cancer
por: Matikas, Alexios, et al.
Publicado: (2018)

Stretching Method-Based Operational Modal Analysis of An Old Masonry Lighthouse
por: Daskalakis, Emmanouil, et al.
Publicado: (2019)

Laparoscopic Gastric Plication for the Treatment of Morbid Obesity: A Review
por: Kourkoulos, Michael, et al.
Publicado: (2012)

Weak stromal Caveolin-1 expression in colorectal liver metastases predicts poor prognosis after hepatectomy for liver-only colorectal metastases
por: Neofytou, Kyriakos, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_eh7crajk6libakqvfk2cdnr88l