Stereoselectivity of Aldose Reductase in the Reduction of Glutathionyl-Hydroxynonanal Adduct

The formation of the adduct between the lipid peroxidation product 4-hydroxy-2-nonenal (HNE) and glutathione, which leads to the generation of 3-glutathionyl-4-hydroxynonane (GSHNE), is one of the main routes of HNE detoxification. The aldo-keto reductase AKR1B1 is involved in the reduction of the a...

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Detalles Bibliográficos
Autores principales: Balestri, Francesco, Barracco, Vito, Renzone, Giovanni, Tuccinardi, Tiziano, Pomelli, Christian Silvio, Cappiello, Mario, Lessi, Marco, Rotondo, Rossella, Bellina, Fabio, Scaloni, Andrea, Mura, Umberto, Del Corso, Antonella, Moschini, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827081/
https://www.ncbi.nlm.nih.gov/pubmed/31652566
http://dx.doi.org/10.3390/antiox8100502

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