Cargando…

CAF-1 Subunits Levels Suggest Combined Treatments with PARP-Inhibitors and Ionizing Radiation in Advanced HNSCC

Oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinomas show high morbidity and mortality rates. We aimed to investigate the role of the “Chromatin Assembly Factor-1” (CAF-1) p60 and p150 subunits, involved in DNA repair and replication, in OSCC and OPSCC progression and in response to Poly(A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morra, Francesco, Merolla, Francesco, Picardi, Ida, Russo, Daniela, Ilardi, Gennaro, Varricchio, Silvia, Liotti, Federica, Pacelli, Roberto, Palazzo, Luca, Mascolo, Massimo, Celetti, Angela, Staibano, Stefania
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827109/ https://www.ncbi.nlm.nih.gov/pubmed/31627329 http://dx.doi.org/10.3390/cancers11101582

Ejemplares similares

Neuropilin-1 Expression Associates with Poor Prognosis in HNSCC and Elicits EGFR Activation upon CDDP-Induced Cytotoxic Stress
por: Napolitano, Virginia, et al.
Publicado: (2021)

The combined effect of USP7 inhibitors and PARP inhibitors in hormone-sensitive and castration-resistant prostate cancer cells
por: Morra, Francesco, et al.
Publicado: (2017)

Tissue Microarray-Based Evaluation of Chromatin Assembly Factor-1 (CAF-1)/p60 as Tumour Prognostic Marker
por: Mascolo, Massimo, et al.
Publicado: (2012)

The disruption of the CCDC6 – PP4 axis induces a BRCAness like phenotype and sensitivity to PARP inhibitors in high-grade serous ovarian carcinoma
por: Morra, Francesco, et al.
Publicado: (2022)

CCDC6 and USP7 expression levels suggest novel treatment options in high-grade urothelial bladder cancer
por: Morra, Francesco, et al.
Publicado: (2019)

Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors
por: Staibano, Stefania, et al.
Publicado: (2013)

Retraction Note: Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors
por: Staibano, Stefania, et al.
Publicado: (2021)

Epigenetics of oral and oropharyngeal cancers (Review)
por: Russo, Daniela, et al.
Publicado: (2020)

Tissue Expression of Carbonic Anhydrase IX Correlates to More Aggressive Phenotype of Basal Cell Carcinoma
por: Russo, Daniela, et al.
Publicado: (2021)

A rare case of coexistence of metastasis from head and neck squamous cell carcinoma and tuberculosis within a neck lymph node
por: Caroppo, Danila, et al.
Publicado: (2015)

Epigenetic Disregulation in Oral Cancer
por: Mascolo, Massimo, et al.
Publicado: (2012)

FKBP51 Immunohistochemical Expression: A New Prognostic Biomarker for OSCC?
por: Russo, Daniela, et al.
Publicado: (2017)

Overexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer
por: Mascolo, Massimo, et al.
Publicado: (2012)

Histopathological Determinants of Tumor Resistance: A Special Look to the Immunohistochemical Expression of Carbonic Anhydrase IX in Human Cancers
por: Ilardi, G., et al.
Publicado: (2014)

HPV Virus Transcriptional Status Assessment in a Case of Sinonasal Carcinoma
por: Ilardi, Gennaro, et al.
Publicado: (2018)

Expression of P16INK4a in Uveal Melanoma: New Perspectives
por: Russo, Daniela, et al.
Publicado: (2020)

A Machine-learning Approach for the Assessment of the Proliferative Compartment of Solid Tumors on Hematoxylin-Eosin-Stained Sections
por: Martino, Francesco, et al.
Publicado: (2020)

Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic
por: Cerrato, Aniello, et al.
Publicado: (2016)

FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC
por: Morra, Francesco, et al.
Publicado: (2015)

Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage
por: Merolla, Francesco, et al.
Publicado: (2012)

New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment
por: Criscuolo, Daniela, et al.
Publicado: (2019)

Identification of Novel Biomarkers of Homologous Recombination Defect in DNA Repair to Predict Sensitivity of Prostate Cancer Cells to PARP-Inhibitors
por: Criscuolo, Daniela, et al.
Publicado: (2019)

NSCLC Mutated Isoforms of CCDC6 Affect the Intracellular Distribution of the Wild Type Protein Promoting Cisplatinum Resistance and PARP Inhibitors Sensitivity in Lung Cancer Cells
por: Cerrato, Aniello, et al.
Publicado: (2019)

The tumour suppressor CCDC6 is involved in ROS tolerance and neoplastic transformation by evading ferroptosis
por: Morra, Francesco, et al.
Publicado: (2021)

NF-Y Subunits Overexpression in HNSCC
por: Bezzecchi, Eugenia, et al.
Publicado: (2021)

A xCT role in tumour-associated ferroptosis shed light on novel therapeutic options
por: Criscuolo, Daniela, et al.
Publicado: (2022)

MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors
por: Rossi, Matteo, et al.
Publicado: (2016)

N-Formyl Peptide Receptors Induce Radical Oxygen Production in Fibroblasts Derived From Systemic Sclerosis by Interacting With a Cleaved Form of Urokinase Receptor
por: Napolitano, Filomena, et al.
Publicado: (2018)

Role of chromatin assembly factor-1/p60 and poly [ADP-ribose] polymerase 1 in mycosis fungoides
por: Mascolo, Massimo, et al.
Publicado: (2020)

OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome
por: Staibano, S, et al.
Publicado: (2007)

Probe-Based Confocal Laser Endomicroscopy Evaluation of Colon Preneoplastic Lesions, with Particular Attention to the Aberrant Crypt Foci, and Comparative Assessment with Histological Features Obtained by Conventional Endoscopy
por: Mascolo, Massimo, et al.
Publicado: (2012)

TBX1 and Basal Cell Carcinoma: Expression and Interactions with Gli2 and Dvl2 Signaling
por: Caprio, Cinzia, et al.
Publicado: (2020)

The between Now and Then of Lung Cancer Chemotherapy and Immunotherapy
por: Visconti, Roberta, et al.
Publicado: (2017)

Histopathological Image Deep Feature Representation for CBIR in Smart PACS
por: Tommasino, Cristian, et al.
Publicado: (2023)

Overexpression of Chromatin Assembly Factor-1/p60 helps to predict the prognosis of melanoma patients
por: Mascolo, Massimo, et al.
Publicado: (2010)

The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones
por: Liu, Wallace H, et al.
Publicado: (2016)

Identification of Sumoylation Sites in CCDC6, the First Identified RET Partner Gene in Papillary Thyroid Carcinoma, Uncovers a Mode of Regulating CCDC6 Function on CREB1 Transcriptional Activity
por: Luise, Chiara, et al.
Publicado: (2012)

The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1
por: Mattiroli, Francesca, et al.
Publicado: (2017)

PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response
por: Wurster, Stephanie, et al.
Publicado: (2016)

PARP Inhibitors Talazoparib and Niraparib Sensitize Melanoma Cells to Ionizing Radiation
por: Jonuscheit, Stephanie, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_07qav06vvooje9v0b27p4ftlpt