Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy

Colorectal patients generally have the maximum counts of Fusobacterium nucleatum (F. nucleatum) in tumors and elevate colorectal adenomas and carcinomas, which show the lowest rate of human survival. Hence, F. nucleatum is a diagnostic marker of colorectal cancer (CRC). Studies demonstrated that tar...

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Autores principales: Ganesan, Kumar, Guo, Songhe, Fayyaz, Sundaz, Zhang, Ge, Xu, Baojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827134/
https://www.ncbi.nlm.nih.gov/pubmed/31635333
http://dx.doi.org/10.3390/cancers11101592
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author Ganesan, Kumar
Guo, Songhe
Fayyaz, Sundaz
Zhang, Ge
Xu, Baojun
author_facet Ganesan, Kumar
Guo, Songhe
Fayyaz, Sundaz
Zhang, Ge
Xu, Baojun
author_sort Ganesan, Kumar
collection PubMed
description Colorectal patients generally have the maximum counts of Fusobacterium nucleatum (F. nucleatum) in tumors and elevate colorectal adenomas and carcinomas, which show the lowest rate of human survival. Hence, F. nucleatum is a diagnostic marker of colorectal cancer (CRC). Studies demonstrated that targeting fusobacterial Fap2 or polysaccharide of the host epithelium may decrease fusobacteria count in the CRC. Attenuated F. nucleatum-Fap2 prevents transmembrane signals and inhibits tumorigenesis inducing mechanisms. Hence, in this review, we hypothesized that application of genetically programmed fusobacterium can be skillful and thus reduce fusobacterium in the CRC. Genetically programmed F. nucleatum is a promising antitumor strategy.
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spelling pubmed-68271342019-11-18 Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy Ganesan, Kumar Guo, Songhe Fayyaz, Sundaz Zhang, Ge Xu, Baojun Cancers (Basel) Review Colorectal patients generally have the maximum counts of Fusobacterium nucleatum (F. nucleatum) in tumors and elevate colorectal adenomas and carcinomas, which show the lowest rate of human survival. Hence, F. nucleatum is a diagnostic marker of colorectal cancer (CRC). Studies demonstrated that targeting fusobacterial Fap2 or polysaccharide of the host epithelium may decrease fusobacteria count in the CRC. Attenuated F. nucleatum-Fap2 prevents transmembrane signals and inhibits tumorigenesis inducing mechanisms. Hence, in this review, we hypothesized that application of genetically programmed fusobacterium can be skillful and thus reduce fusobacterium in the CRC. Genetically programmed F. nucleatum is a promising antitumor strategy. MDPI 2019-10-18 /pmc/articles/PMC6827134/ /pubmed/31635333 http://dx.doi.org/10.3390/cancers11101592 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ganesan, Kumar
Guo, Songhe
Fayyaz, Sundaz
Zhang, Ge
Xu, Baojun
Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy
title Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy
title_full Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy
title_fullStr Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy
title_full_unstemmed Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy
title_short Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy
title_sort targeting programmed fusobacterium nucleatum fap2 for colorectal cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827134/
https://www.ncbi.nlm.nih.gov/pubmed/31635333
http://dx.doi.org/10.3390/cancers11101592
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