Juvenile systemic lupus erythematosus presenting as pancarditis

BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with marked variation in its clinical presentation. Juvenile SLE (jSLE) accounts for 15–20% of all cases and is diagnosed when SLE manifests before 18 years of age. Pancarditis is a rare complication of SLE, regardless of...

Descripción completa

Detalles Bibliográficos
Autores principales: O’Leary, D., O’Connor, C., Nertney, L., MacDermott, E. J., Mullane, D., Franklin, O., Killeen, O. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827175/
https://www.ncbi.nlm.nih.gov/pubmed/31684978
http://dx.doi.org/10.1186/s12969-019-0372-z
_version_ 1783465261742948352
author O’Leary, D.
O’Connor, C.
Nertney, L.
MacDermott, E. J.
Mullane, D.
Franklin, O.
Killeen, O. G.
author_facet O’Leary, D.
O’Connor, C.
Nertney, L.
MacDermott, E. J.
Mullane, D.
Franklin, O.
Killeen, O. G.
author_sort O’Leary, D.
collection PubMed
description BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with marked variation in its clinical presentation. Juvenile SLE (jSLE) accounts for 15–20% of all cases and is diagnosed when SLE manifests before 18 years of age. Pancarditis is a rare complication of SLE, regardless of age of disease onset. CASE PRESENTATION: We report a case of jSLE in a 15 year old Caucasian female presenting with an acute episode of pancarditis and multiorgan dysfunction who was successfully treated with systemic corticosteroids and cyclophosphamide. CONCLUSION: Pancarditis can be a presenting feature of jSLE which was previously unreported. A high index of suspicion for severe cardiac involvement is required at all stages of disease.
format Online
Article
Text
id pubmed-6827175
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-68271752019-11-07 Juvenile systemic lupus erythematosus presenting as pancarditis O’Leary, D. O’Connor, C. Nertney, L. MacDermott, E. J. Mullane, D. Franklin, O. Killeen, O. G. Pediatr Rheumatol Online J Case Report BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with marked variation in its clinical presentation. Juvenile SLE (jSLE) accounts for 15–20% of all cases and is diagnosed when SLE manifests before 18 years of age. Pancarditis is a rare complication of SLE, regardless of age of disease onset. CASE PRESENTATION: We report a case of jSLE in a 15 year old Caucasian female presenting with an acute episode of pancarditis and multiorgan dysfunction who was successfully treated with systemic corticosteroids and cyclophosphamide. CONCLUSION: Pancarditis can be a presenting feature of jSLE which was previously unreported. A high index of suspicion for severe cardiac involvement is required at all stages of disease. BioMed Central 2019-11-04 /pmc/articles/PMC6827175/ /pubmed/31684978 http://dx.doi.org/10.1186/s12969-019-0372-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
O’Leary, D.
O’Connor, C.
Nertney, L.
MacDermott, E. J.
Mullane, D.
Franklin, O.
Killeen, O. G.
Juvenile systemic lupus erythematosus presenting as pancarditis
title Juvenile systemic lupus erythematosus presenting as pancarditis
title_full Juvenile systemic lupus erythematosus presenting as pancarditis
title_fullStr Juvenile systemic lupus erythematosus presenting as pancarditis
title_full_unstemmed Juvenile systemic lupus erythematosus presenting as pancarditis
title_short Juvenile systemic lupus erythematosus presenting as pancarditis
title_sort juvenile systemic lupus erythematosus presenting as pancarditis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827175/
https://www.ncbi.nlm.nih.gov/pubmed/31684978
http://dx.doi.org/10.1186/s12969-019-0372-z
work_keys_str_mv AT olearyd juvenilesystemiclupuserythematosuspresentingaspancarditis
AT oconnorc juvenilesystemiclupuserythematosuspresentingaspancarditis
AT nertneyl juvenilesystemiclupuserythematosuspresentingaspancarditis
AT macdermottej juvenilesystemiclupuserythematosuspresentingaspancarditis
AT mullaned juvenilesystemiclupuserythematosuspresentingaspancarditis
AT franklino juvenilesystemiclupuserythematosuspresentingaspancarditis
AT killeenog juvenilesystemiclupuserythematosuspresentingaspancarditis

Ejemplares similares