A BRET-based assay reveals collagen–Hsp47 interaction dynamics in the endoplasmic reticulum and small-molecule inhibition of this interaction

Molecular chaperones perform pivotal roles in proteostasis by engaging in protein–protein interactions (PPIs). The collagen-specific molecular chaperone Hsp47 (heat shock protein 47) interacts with procollagen in the endoplasmic reticulum (ER) and plays crucial roles in collagen synthesis. PPIs betw...

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Detalles Bibliográficos
Autores principales: Ito, Shinya, Saito, Masazumi, Yoshida, Masahito, Takeuchi, Koh, Doi, Takayuki, Nagata, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827286/
https://www.ncbi.nlm.nih.gov/pubmed/31492754
http://dx.doi.org/10.1074/jbc.RA119.010567

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