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Vision Parameters Most Important to Functionality in Glaucoma

PURPOSE: To determine the importance of various vision parameters to functionality in glaucoma. METHODS: Vision was measured using seven parameters: visual acuity (VA), contrast sensitivity (CS), integrated visual field (IVF), area under the log CS function (AULCSF), color vision, stereoacuity, and...

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Autores principales: Shakarchi, Ahmed F., Mihailovic, Aleksandra, West, Sheila K., Friedman, David S., Ramulu, Pradeep Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827423/
https://www.ncbi.nlm.nih.gov/pubmed/31675073
http://dx.doi.org/10.1167/iovs.19-28023
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author Shakarchi, Ahmed F.
Mihailovic, Aleksandra
West, Sheila K.
Friedman, David S.
Ramulu, Pradeep Y.
author_facet Shakarchi, Ahmed F.
Mihailovic, Aleksandra
West, Sheila K.
Friedman, David S.
Ramulu, Pradeep Y.
author_sort Shakarchi, Ahmed F.
collection PubMed
description PURPOSE: To determine the importance of various vision parameters to functionality in glaucoma. METHODS: Vision was measured using seven parameters: visual acuity (VA), contrast sensitivity (CS), integrated visual field (IVF), area under the log CS function (AULCSF), color vision, stereoacuity, and VA with noise (ViN). Likelihood ratio testing (LRT) determined if the full set of visual parameters significantly explained variability in 10 functional outcomes. For outcomes where the visual contribution was significant, dominance analysis determined the relative importance of the various visual parameters. RESULTS: The analysis included 151 glaucoma patients. Mean age was 70 ± 6.8 years, and 47% were men. Significant visual contributions (LRT P < 0.05) were noted for glaucoma quality of life (GQL-15), reading speed, driving cessation, daily steps, and base of support while walking, but not for fear of falling, balance, gait velocity, stride velocity, and stride length while walking (LRT P > 0.05). The most important parameter (and percent contribution) to vision-explained variability were AULCSF for daily steps (45%), IVF for base of support (35%), VA for reading speed (34%), CS for GQL-15 (30%), and VA for driving cessation (26%). CONCLUSIONS: Measures of visual ability are important for several aspects of quality of life and functionality. The most important vision parameter for functionality differs depending on the domain studied. Reading and driving were explained by VA and IVF sensitivity. On the other hand, GQL-15 and daily steps were more heavily influenced by CS and AULCSF, which are rarely performed clinically.
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spelling pubmed-68274232019-11-05 Vision Parameters Most Important to Functionality in Glaucoma Shakarchi, Ahmed F. Mihailovic, Aleksandra West, Sheila K. Friedman, David S. Ramulu, Pradeep Y. Invest Ophthalmol Vis Sci Glaucoma PURPOSE: To determine the importance of various vision parameters to functionality in glaucoma. METHODS: Vision was measured using seven parameters: visual acuity (VA), contrast sensitivity (CS), integrated visual field (IVF), area under the log CS function (AULCSF), color vision, stereoacuity, and VA with noise (ViN). Likelihood ratio testing (LRT) determined if the full set of visual parameters significantly explained variability in 10 functional outcomes. For outcomes where the visual contribution was significant, dominance analysis determined the relative importance of the various visual parameters. RESULTS: The analysis included 151 glaucoma patients. Mean age was 70 ± 6.8 years, and 47% were men. Significant visual contributions (LRT P < 0.05) were noted for glaucoma quality of life (GQL-15), reading speed, driving cessation, daily steps, and base of support while walking, but not for fear of falling, balance, gait velocity, stride velocity, and stride length while walking (LRT P > 0.05). The most important parameter (and percent contribution) to vision-explained variability were AULCSF for daily steps (45%), IVF for base of support (35%), VA for reading speed (34%), CS for GQL-15 (30%), and VA for driving cessation (26%). CONCLUSIONS: Measures of visual ability are important for several aspects of quality of life and functionality. The most important vision parameter for functionality differs depending on the domain studied. Reading and driving were explained by VA and IVF sensitivity. On the other hand, GQL-15 and daily steps were more heavily influenced by CS and AULCSF, which are rarely performed clinically. The Association for Research in Vision and Ophthalmology 2019-11 /pmc/articles/PMC6827423/ /pubmed/31675073 http://dx.doi.org/10.1167/iovs.19-28023 Text en Copyright 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Glaucoma
Shakarchi, Ahmed F.
Mihailovic, Aleksandra
West, Sheila K.
Friedman, David S.
Ramulu, Pradeep Y.
Vision Parameters Most Important to Functionality in Glaucoma
title Vision Parameters Most Important to Functionality in Glaucoma
title_full Vision Parameters Most Important to Functionality in Glaucoma
title_fullStr Vision Parameters Most Important to Functionality in Glaucoma
title_full_unstemmed Vision Parameters Most Important to Functionality in Glaucoma
title_short Vision Parameters Most Important to Functionality in Glaucoma
title_sort vision parameters most important to functionality in glaucoma
topic Glaucoma
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827423/
https://www.ncbi.nlm.nih.gov/pubmed/31675073
http://dx.doi.org/10.1167/iovs.19-28023
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